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Development of functional feed additives by encapsulation of α-tocopherol in β-cyclodextrin and co-treatment of α-linolenic acid / betaine
알파-토코페롤의 베타-사이클로덱스트린 내 캡슐화 및 알파-리놀렌산 과 베테인 동시 처리를 통한 기능성 사료첨가제의 개발

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Authors
허윤정
Advisor
최윤재
Major
농업생명과학대학 농생명공학부
Issue Date
2015-02
Publisher
서울대학교 대학원
Keywords
α-tocopherolβ-cyclodextrinsurfactantsspray dryingα- linolenic acidω-6/ω-3 balancebetainemuscle growthfeed additives
Description
학위논문 (석사)-- 서울대학교 대학원 : 농생명공학부, 2015. 2. 최윤재.
Abstract
Functional materials are agents that have biological function with small
amount, such as vitamins, hormones and neurotransmitters. There are various
types of functional materials, and their biological functions can be classified
into anti-inflammation effect, anti-oxidation effect and methyl-group donation
etc. Functional materials are on the border between food and medicine because
of its high efficiency of biological functions. Especially, many types of
functional materials are contained in livestock products, and by strengthening
the amount of those materials, functional livestock products can be produced.
Functional bioactive materials have some obstacles until entering into the
body and functioning. Because of low stability in high temperature or UV light,
they can be degraded during storage, delivery and processing. After intake, the
low pH in stomach and enzymatic reaction can degrade the functional
molecules. Furthermore, many of the functional materials such as unsaturated
fatty acids or lipophilic vitamins are hardly dissolved in water, resulting in low
absorption rate by intestinal epithelial barrier. The low stability and low
bioavailability of the material are the key obstacles of their usage.
To overcome this obstacles, we tried two strategies. The first study is
encapsulating α-tocopherol in β-CD with surfactant mixture system. β-CD is
popular encapsulation material which can include other hydrophobic material
inside of its cyclic structure, forming inclusion complex. But β-CD
encapsulation still has limited solubility, and has no way of optimization for II
each guest molecule. So, we used surfactant mixture system together with β-
CD encapsulation to improve the solubility and optimize encapsulation
efficiency and release efficiency. The second study is about determining
synergistic effect of ALA and betaine. By finding out synergistic composition
of ALA and betaine, we can develop feed additives composed of two synergistic
materials together.
In chapter 1, α-tocopherol was encapsulated in β-CD with various ratio of
tween 80 and span 80. The encapsulated α-tocopherol showed better
encapsulation efficiency, better release rate, better stability, and finally
enhanced accumulation of α-tocopherol in yolk when supplemented to hens. In
chapter 2, the synergistic effect of ALA and betaine on myoblast proliferation
and differentiation was analyzed. Single treatment of ALA and betaine had a
little effect on myoblast proliferation or differentiation, but co-treatment of
ALA and betaine enhanced both proliferation and differentiation of myoblasts.
These results indicated that α-tocopherol encapsulation can enhance better
stability and bioavailability, which can be applied to developing efficient
functional feed additives. Moreover, ALA and betaine were found out to be
have synergistic effect, so supplement of ALA and betaine together to animals
probably have better effects than single supplement of ALA or betaine.
Language
English
URI
http://hdl.handle.net/10371/125889
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College of Agriculture and Life Sciences (농업생명과학대학)Dept. of Agricultural Biotechnology (농생명공학부)Theses (Master's Degree_농생명공학부)
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