S-Space College of Engineering/Engineering Practice School (공과대학/대학원) Dept. of Chemical and Biological Engineering (화학생물공학부) Theses (Master's Degree_화학생물공학부)
Hydrogel microcontainers with tunable physical properties prepared by polyionic complexation : 이온 복합체 형성을 통해 물리적 성질 조절이 가능한 수화젤 마이크로 수송체 구조에 관한 연구
Cited 0 time in Web of Science Cited 0 time in Scopus
- 공과대학 화학생물공학부
- Issue Date
- 서울대학교 대학원
- 학위논문 (석사)-- 서울대학교 대학원 : 화학생물공학부, 2013. 2. 차국헌.
- Synthesis of hydrogel hollow capsules provides the opportunity to extend the applications of gel materials as carriers. We report on biocompatible poly(vinylamine) (PVAm) hydrogel hollow microcontainers derived from well-defined precursor polymer, poly(N-vinylformamide) (PNVF). Herein, PNVF particles were synthesized via dispersion polymerization, varying either of crosslinking agent concentrations or steric stabilizer concentrations with the aim of probing the key factors that facilitate hollow structure. Uniform PVAm hydrogel capsules were consecutively prepared from PNVF, provided PNVF were attained in a sufficiently cross-linked structure.
Subsequently, taking advantage of protonated amine in PVAm at alkaline condition, we constructed PVAm-hyaluronic acid (HA) complexes with two descriptions of HA, possessing different molecular weight. We thus confirmed complex structures with NMR cryoporometry analysis that PVAm-short HA chain complexes (PVAm-SHA) contains denser shell structure than that of PVAm-long HA chain complex (PVAm-LHA). This, in turn, leads to the PVAm-SHA with higher stability against external stimuli, near-infrared (NIR) laser irradiation. For imparting light absorption in NIR region, we introduced gold nanorod (AuNR) to the PVAm-HA complexes. Consequently, PVAm-SHA exhibited improved durability and light stability when compared with PVAm-LHA during the local heating of AuNRs by NIR irradiation.
In this study, we thus practically synthesized hydrogel hollow capsules in different size and also verified the structural change of polyion shell complexes by varying the chain length of HA, leading to enhancement of mechanical strength and light durability. As a consequence, the hollow PVAm-HA capsules developed in the present study can serve as promising microcontainers for therapeutic delivery systems.
- Files in This Item:
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.