Browse

Decrease in KAI1/CD82 expression of mural cells in response to angiogenic stimulus
혈관신생 촉진 자극이 주피세포 발현 항혈관신생 인자인 KAI1/CD82의 발현에 미치는 영향에 관한 연구

Cited 0 time in Web of Science Cited 0 time in Scopus
Authors
남브니엘
Advisor
김효수
Major
의과대학 협동과정줄기세포생물학전공
Issue Date
2017-02
Publisher
서울대학교 대학원
Keywords
혈관신생혈관 내피세포혈관 벽세포테트라스파닌카이-원DNA 메틸화세포 내 섭취
Description
학위논문 (석사)-- 서울대학교 대학원 : 협동과정 줄기세포생물학 전공, 2017. 2. 김효수.
Abstract
Recent studies have highlighted the role of mural cells and tetraspanin molecules in angiogenesis. We and others [1] previously observed that mice that lack KAI1 (also known as CD82), a tetraspanin family member, display higher angiogenic capacity compared to their WT counterpart. Intriguingly, KAI1 was primarily expressed on mural (perivascular) cells in both humans and mice. We next asked if KAI1 expression changes in response to angiogenic stimuli. Angiogenic cytokines reversibly reduced mRNA level of KAI1 in mural cells through Src/PKC-DNMT3A-mediated DNA methylation of Kai1 promoter region. On the other hand, endothelial KAI1 expression showed no significant changes upon angiokine treatment. Furthermore, protein level of KAI1 also was rapidly lowered upon cytokine stimulation through endocytosis. Our study suggests perivascular KAI1 may act as a switch regulating the transition between vessel quiescence and angiogenesis.
Language
English
URI
https://hdl.handle.net/10371/132278
Files in This Item:
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Program in Stem Cell Biology (협동과정-줄기세포생물학전공)Theses (Master's Degree_협동과정-줄기세포생물학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse