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Probiotic suppression of the H. pylori-induced responses by conjugated linoleic acids in a gastric epithelial cell line : 포합 리놀레산에 의한 위상피세포주 내 헬리코박터균 반응의 억제
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- Authors
- Advisor
- 정현채
- Major
- 의과대학 의학과
- Issue Date
- 2014-02
- Publisher
- 서울대학교 대학원
- Keywords
- Helicobacter pylori ; Probiotics ; Conjugated linoleic acids ; Interleukin-8 ; Tumor necrosis factor-alpha ; Inducible nitric oxide synthase
- Description
- 학위논문 (석사)-- 서울대학교 대학원 : 의학과, 2014. 2. 정현채.
- Abstract
- Introduction: Conjugated linoleic acids (CLA) produced by Lactobacillus acidophilus was reported to decrease the activation of nuclear factor-kappa B. CLA was suggested as one of the anti-inflammatory molecular mechanisms of probiotics. In the present study, the effects of CLA on H. pylori-induced multiple responses were evaluated.
Methods: IL-8, TNF-α and iNOS were measured in mRNA and/or protein levels in AGS cells after pretreatment with CLA or CLA-containing conditioned medium (CM) produced by Lactobacillus acidophilus or Lactobacillus plantarum.
Results: The increased expressions of IL-8 mRNA/protein and TNF-α mRNA were significantly suppressed by pretreatment with CM or CLA. The levels of IL-8 protein and TNF-α mRNA were suppressed by CM pretreatment better than CLA. The expression of iNOS mRNA was also significantly inhibited by CM pretreatment.
Conclusions: These results suggest that the suppression of multiple mediators by CLA-containing CM plays a key role in the anti-inflammatory and anti-carcinogenic effects of probiotics on H. pylori infection.
- Language
- Korean
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