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Protective immunity induced by Respiratory Syncytial Virus Glycoprotein fragment in Neonatal Mice

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Authors
노유란
Advisor
강창율
Major
융합과학기술대학원 분자의학 및 바이오제약학과
Issue Date
2012-08
Publisher
서울대학교 대학원
Keywords
Respiratory syncytial virusGlycoproteinNeonateVaccineMaternal effectMucosal
Description
학위논문 (석사)-- 서울대학교 융합과학기술대학원 : 분자의학 및 바이오제약학과, 2012. 8. 강창율.
Abstract
Respiratory syncytial virus (RSV) is the major cause of severe lower respiratory tract infection in infants and the elderly worldwide. The significant morbidity and mortality associated with this infection underscores the urgent need for an RSV vaccine development. In this study, we firstly showed that intranasal administration of RSV glycoprotein core fragment (Gcf) to neonatal mice was capable of inducing systemic humoral immune responses and had protective efficacy against RSV without lung eosinophilia, though antibody response was shifted to Th2. Next, we examined whether the presence of maternal anti-RSV antibodies affects the responsiveness and protection efficacy of Gcf in newborn mice, since infants can have RSV specific maternal antibodies due to frequent re-infection of RSV to adults. Intranasal administration of Gcf induced antibody response, IFN-γ secretion and protected mice against RSV challenge without lung eosinophilia even in the presence of high level of RSV-specific maternal antibodies. Thus, our study suggests that Gcf can be applied as an effective and safe RSV vaccine during the neonatal period.
Language
English
URI
https://hdl.handle.net/10371/133320
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Graduate School of Convergence Science and Technology (융합과학기술대학원)Dept. of Molecular and Biopharmaceutical Sciences (분자의학 및 바이오제약학과)Theses (Master's Degree_분자의학 및 바이오제약학과)
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