Publications
Detailed Information
Separacenes A–C, Cytotoxic Polyene Polyketides from the Marine Actinomycete, Streptomyces sp.
Cited 0 time in
Web of Science
Cited 0 time in Scopus
- Authors
- Advisor
- 오 동 찬
- Major
- 약학대학 약학과
- Issue Date
- 2013-02
- Publisher
- 서울대학교 대학원
- Keywords
- linear polyketides ; separacene ; marine actinomycete.
- Description
- 학위논문 (석사)-- 서울대학교 대학원 : 약학과, 2013. 2. 오동찬.
- Abstract
- During our search for new secondary metabolites with pharmaceutical potential, marine actinomycete strains, collected from Shinyang Beach in Jeju Island, were chemically analyzed by LC/MS. One of the marine actinomycetes strains, SNW10 (Streptomyces sp. based on 16S rDNA analysis), was revealed to produce unique tetraene / triene-bearing metabolites, which named separacenes A-C. The structures of the separacenes were determined by spectroscopic analysis of 1D and 2D NMR, MS and UV data. Separacene A possessing terminal olefinic double bond, conjugated tetraene, and two 1,2-diol groups, turned out to be a new 15-membered linear polyketide. The absolute configuration of separacene A was established by modified Moshers method. The structures of separacene B and C, which incorporate terminal olefinic methylene, tirene, and two 1,2-diol moieties, were also elucidated by spectroscopic analysis and chemical derivatization. Separacene A displayed cytotoxic activity against the HCT116 and A549 cancer cell line.
- Language
- English
- Files in This Item:
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.