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Separacenes A–C, Cytotoxic Polyene Polyketides from the Marine Actinomycete, Streptomyces sp.

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Authors
배문형
Advisor
오 동 찬
Major
약학대학 약학과
Issue Date
2013-02
Publisher
서울대학교 대학원
Keywords
linear polyketidesseparacenemarine actinomycete.
Description
학위논문 (석사)-- 서울대학교 대학원 : 약학과, 2013. 2. 오동찬.
Abstract
During our search for new secondary metabolites with pharmaceutical potential, marine actinomycete strains, collected from Shinyang Beach in Jeju Island, were chemically analyzed by LC/MS. One of the marine actinomycetes strains, SNW10 (Streptomyces sp. based on 16S rDNA analysis), was revealed to produce unique tetraene / triene-bearing metabolites, which named separacenes A-C. The structures of the separacenes were determined by spectroscopic analysis of 1D and 2D NMR, MS and UV data. Separacene A possessing terminal olefinic double bond, conjugated tetraene, and two 1,2-diol groups, turned out to be a new 15-membered linear polyketide. The absolute configuration of separacene A was established by modified Moshers method. The structures of separacene B and C, which incorporate terminal olefinic methylene, tirene, and two 1,2-diol moieties, were also elucidated by spectroscopic analysis and chemical derivatization. Separacene A displayed cytotoxic activity against the HCT116 and A549 cancer cell line.
Language
English
URI
https://hdl.handle.net/10371/133453
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College of Pharmacy (약학대학)Dept. of Pharmacy (약학과)Theses (Master's Degree_약학과)
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