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MuSK antibody-positive, seronegative myasthenia gravis in Korea
Cited 26 time in
Web of Science
Cited 33 time in Scopus
- Authors
- Issue Date
- 2006-03-21
- Publisher
- Elsevier
- Citation
- J Clin Neurosci. 2006 Apr;13(3):353-5. Epub 2006 Mar 20.
- Keywords
- Adolescent ; Adult ; Age of Onset ; Antibodies/*blood ; Child ; Child, Preschool ; Female ; Humans ; Immunosuppressive Agents/pharmacology ; Infant ; Korea/epidemiology ; Male ; Middle Aged ; Myasthenia Gravis/*blood/*immunology/therapy ; Receptor Protein-Tyrosine Kinases/*immunology ; Receptors, Cholinergic/*immunology ; Severity of Illness Index ; Thymectomy/methods
- Abstract
- Several reports from Western countries suggest differences in the clinical features of patients with muscle specific kinase (MuSK) antibody-positive and -negative seronegative myasthenia gravis (MG). We performed the first survey in Korea of MuSK antibodies, studying 23 patients with acetylcholine receptor (AChR)-antibody seronegative MG. MuSK antibodies were present in 4 (26.7%) of 15 generalized seronegative MG patients and none of 8 ocular seronegative MG patients. All four MuSK positive patients were females, with pharyngeal and respiratory muscle weakness, and required immunosuppressive treatment. However, overall disease severity and age at onset was similar to that of MuSK-negative MG and treatment responses were equally good.
- ISSN
- 0967-5868 (Print)
- Language
- English
- URI
- http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WHP-4JHMXX2-7&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=13ad3a069651af3cf0ad687e4e737f69
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16546389
https://hdl.handle.net/10371/13464
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