S-Space College of Medicine/School of Medicine (의과대학/대학원) Psychiatry (정신과학전공) Journal Papers (저널논문_정신과학전공)
Associations of thyroid hormone serum levels with in-vivo Alzheimers disease pathologies
- Choi, Hyo Jung; Byun, Min Soo; Yi, Dahyun; Sohn, Bo Kyung; Lee, Jun Ho; Lee, Jun-Young; Kim, Yu Kyung; Lee, Dong Young
- Issue Date
- BioMed Central
- Alzheimer's Research & Therapy, 9(1):64
- Beta-amyloid; Neurodegeneration; Thyroid hormone; Thyroid-stimulating hormone; Alzheimer’s disease; Biomarker
AAL: Automated Anatomical Labeling; AD: Alzheimers disease; APOE: Apolipoprotein E; APP: Beta-amyloid precursor protein; Aβ: Amyloid beta; BBB: Blood–brain barrier; CERAD-K: Consortium to Establish a Registry for Alzheimers Disease Assessment Packet; CMglu: Cerebral glucose metabolism; CN: Cognitively normal; FDG: 8 F-Deoxyglucose; FLAIR: Fluid-attenuated inversion recovery; fT3: Free T3; fT4: Free thyroxine; KBASE: Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimers Disease; MNI: Montreal Neurological Institute; MRI: Magnetic resonance imaging; PCC: Posterior cingulate cortex; PET: Positron emission tomography; PiB: 11C-Pittsburgh Compound B; ROI: Region of interest; SPM8: Statistical Parametric Mapping 8; SUVR: Standardized uptake value ratio; T3: Total triiodothyronine; TIA: Transient ischemic attack; TSH: Thyroid-stimulating hormone; UTE: Ultrashort echo time; VRS: Vascular risk score
The present study investigated the relationships between thyroid hormone serum levels or thyroid-stimulating hormone (TSH) and two Alzheimers disease (AD)-specific biomarkers, cerebral amyloid beta (Aβ) burden and glucose metabolism, in AD-signature brain regions in cognitively normal (CN) middle-aged and older individuals.
This study assessed 148 CN individuals who received comprehensive clinical and neuropsychological assessments that included 11C-Pittsburgh Compound B (PiB)-positron emission tomography (PET) scans, 18F-deoxyglucose (FDG)-PET scans, and the quantification of serum triiodothyronine (T3), free T3, free thyroxine (fT4), and TSH levels.
All participants were clinically euthyroid. Independent negative associations were found between serum fT4 levels and global cerebral Aβ deposition after controlling for the effects of age, gender, and the apolipoprotein E ε4 (APOEε4) genotype. Although serum TSH levels were not associated with global cerebral Aβ deposition, they had a significant negative association with glucose metabolism in the precuneus/posterior cingulate cortex after controlling for age, gender, and the APOEε4 genotype. No other thyroid hormones exhibited relationships with either brain Aβ burden or glucose metabolism.
Even in a clinical euthyroid state, low serum fT4 and high serum TSH levels appear to be differentially associated with AD-specific brain changes.