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College of Medicine/School of Medicine (의과대학/대학원)
Pediatrics (소아과학전공)
Journal Papers (저널논문_소아과학전공)
Coding single nucleotide polymorphism in the high-affinity immunoglobulin E receptor b chain (FcepsilonRI-beta) gene is associated with immunoglobulin E receptor-mediated histamine release from basophils
- Authors
- Issue Date
- 2002-05-08
- Publisher
- Blackwell Publishing
- Citation
- Clin Exp Allergy. 2002 May;32(5):751-5.
- Keywords
- Adolescent ; Alleles ; Asthma/*genetics ; Basophils/*immunology/metabolism ; Calcimycin/pharmacology ; Child ; Female ; Histamine Release/drug effects/physiology ; Humans ; Male ; Polymorphism, Single Nucleotide ; Random Allocation ; Receptors, IgE/*genetics/*physiology
- Abstract
- BACKGROUND: Our previous work on linkage analysis showed that histamine release from basophils to anti-IgE stimuli was linked to the gene marker of chromosome 11q13, where the beta chain of the high-affinity receptor for IgE (FcepsilonRI-beta) is located. OBJECTIVE: To evaluate the association between FcepsilonRI-mediated histamine release from basophils and four bi-allelic single nucleotide polymorphisms of the FcepsilonRI-beta gene. METHODS: Phenotypes of asthma, such as maximal histamine release from basophils and atopy, were measured from 80 randomly recruited asthmatic children. Polymorphisms of the FcepsilonRI-beta gene were determined by PCR-based methods. RESULTS: The polymorphism in exon 7, resulting in Glu to Gly substitution, was significantly associated with histamine release from basophils to anti-IgE stimuli, but not with total IgE levels and skin test responses to aeroallergens. CONCLUSION: This study supports a role for the FcepsilonRI-beta gene in the expression of high affinity IgE receptor-mediated histamine release from basophils.
- ISSN
- 0954-7894 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11994101
https://hdl.handle.net/10371/13869
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- College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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