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The association between soluble klotho and cardiovascular parameters in chronic kidney disease: results from the KNOW-CKD study

Cited 20 time in Web of Science Cited 20 time in Scopus
Authors
Kim, Hyo Jin; Kang, Eunjeong; Oh, Yun Kyu; Kim, Yeong Hoon; Han, Seung Hyeok; Yoo, Tae Hyun; Chae, Dong-Wan; Lee, Joongyub; Ahn, Curie; Oh, Kook-Hwan
Issue Date
2018-03-05
Publisher
BioMed Central
Citation
BMC Nephrology, 19(1):51
Keywords
Serum klothoSoluble klothoChronic kidney diseaseLeft ventricular mass indexLeft ventricular hypertrophyPulse wave velocity
Abstract
Background
Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The present study aimed to investigate the association between serum klotho and cardiac parameters from a large-scale Korean CKD cohort.

Methods
We analyzed 2101 participants from KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort who had been measured for serum klotho levels. Left ventricular hypertrophy evaluated by left ventricular mass index (LVMI) and arterial stiffness measured by brachial-to-ankle pulse wave velocity (baPWV) were explored as cardiovascular parameters.

Results
Patients were 53.6 ± 12.2 years old and 61.1% were male. The mean estimated glomerular filtration rate (eGFR) was 53.0 ± 30.7 mL/min/1.73m2. The median serum klotho level was 536 (interquartile range [IQR]: 420–667) pg/mL. Advanced CKD stages were associated with lower serum klotho levels (P < 0.001, P for linear trend < 0.001). Ascending quartiles of klotho were significantly associated with decreased LMVI (P < 0.001, P for linear trend< 0.001). A multivariable linear regression model showed serum klotho had a significant inverse association with LVMI (β − 0.04; 95% CI [confidence interval] -0.004, − 0.00007; P = 0.041). However, there was no significant association between serum klotho and baPWV after adjustment (β 0.003; 95% CI -0.04, 0.05; P = 0.876).

Trial registration
This trial was registered on ClinicalTrials.gov on 28 June 2012 (NCT01630486).

Conclusions
Serum klotho was an independent biomarker of LVMI, but not arterial stiffness.
ISSN
1471-2369
Language
English
URI
https://hdl.handle.net/10371/139657
DOI
https://doi.org/10.1186/s12882-018-0851-3
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College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
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