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Bioglas-incorporated gelatin based cryogel for osteogenic commitment of mesenchymal stem cell : 바이오글라스 기반 생체재료를 통한 줄기세포의 골형성 유발
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- Authors
- Advisor
- 황석연
- Major
- 공과대학 화학생물공학부
- Issue Date
- 2018-02
- Publisher
- 서울대학교 대학원
- Keywords
- Methacrylated gelatin ; bioglass ; hydrogel ; bone tissue engineering
- Description
- 학위논문 (석사)-- 서울대학교 대학원 : 공과대학 화학생물공학부, 2018. 2. 황석연.
- Abstract
- Bioglass is widely used in medical field as an excellent biomaterial due to its osteo-inducing effect and biocompatibility. However, due to its brittleness, bioglass alone is not an ideal material for implantation. Characteristics of ideal scaffold using in bone tissue engineering are biocompatibility, high pore size, biodegradability, and mechanical property. Methacrylated gelatin (GelMA), which is a modified gelatin form, retains cell adhesion site, which is a well-suited material for cryogel fabrication. Herein, we fabricated bioglass-incorporated GelMA cryogel for testing osteogenic effect. We demonstrated that as doses of bioglass concentration in scaffolds increases, osteogenic effect on mesenchymal cells increases in in vitro testing. Furthermore, in vivo testing supports that bioglass incorporated GelMA cryogel induces stronger osteogenic differentiation on mesenchymal stem cells than the control group, GelMA cryogel.
In this paper, the enhancement of osteogenic effect using bioglass embedded GelMA scaffold will be presented.
- Language
- English
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