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A Mathematical Model of Hepatitis A Virus Transmission and Its Application for Adult Vaccination Strategy in Korea : 수학적 모델링을 이용한 국내 A형간염 전파 특성 및 성인대상 예방접종 효과 연구

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Authors
정성목
Advisor
조성일
Major
보건대학원 보건학과
Issue Date
2018-02
Publisher
서울대학교 대학원
Keywords
Hepatitis AMathematical modelTransmission dynamicsAdult vaccination
Description
학위논문 (석사)-- 서울대학교 대학원 : 보건대학원 보건학과, 2018. 2. 조성일.
Abstract
Despite universal child vaccination programs and mandatory surveillance systems, the incidence rate of Hepatitis A virus (HAV) recently increased rapidly in Republic of Korea (Korea). Previous studies conducted in Korea developed mathematical models of HAV and projected the effectiveness of child vaccination
however, there were no studies done using empirical data upon introduction of the National Immunization Programs child vaccination program. In this study, we proposed an age-structured dynamic model calibrated with recent empirical data, in order to understand the transmission dynamics of HAV infection and evaluate the impact of diverse adults vaccination strategies as an application of this model.
Although there were some unavoidable assumptions within the model due to lack of underlying information, the projected results fitted well with the empirical data with respect to epidemiology and anti-HAV seroprevalence. Moreover, when compared with the equivalent vaccine coverage, the results indicated that the HAV vaccination for those in their 30s were more effective than that of those in their 20s. Furthermore, when the first dose coverage is greater than 20% and the second dose coverage is at 95%, after a time of eight years, the percentage reduction of notification case is approximately 50%. Sensitivity analysis indicated that the waning rate and proportion of primary vaccine failure could be a fundamental factor in predicting the future epidemic curve of an HAV infection.
The model indicated adult vaccination for 30s can be practical and effective intervention to reduce the burden of HAV in Korea.
Language
English
URI
https://hdl.handle.net/10371/141902
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Graduate School of Public Health (보건대학원)Dept. of Public Health (보건학과)Theses (Master's Degree_보건학과)
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