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Sensitive determination of nonsteroidal anti-inflammatory drugs using 3-phase direct immersion single drop microextraction in-line coupled with capillary electrophoresis
비스테로이드성 소염진통제의 분석감도 개선을 위한 미세방울 추출법과 연동된 모세관 전기영동법

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Authors
최지은
Advisor
정두수
Major
자연과학대학 화학부
Issue Date
2018-02
Publisher
서울대학교 대학원
Keywords
Single drop microextractionCapillary electrophoresisDirect immersionNonsteroidal anti-inflammatory drugs
Description
학위논문 (석사)-- 서울대학교 대학원 : 자연과학대학 화학부, 2018. 2. 정두수.
Abstract
A direct immersion (DI)-single drop microextraction (SDME) in the 3-phase mode was in-line coupled with capillary electrophoresis to improve the detection sensitivity for weakly acidic nonsteroidal anti-inflammatory drugs, such as ketoprofen, ibuprofen, and naproxen in solution. The acidic analytes in an acidified sample donor solution were extracted into a basic acceptor drop covered with a thin organic layer attached to the tip of a separation capillary. Due to the small dimensions of the acceptor and the organic phases, quite high enrichment factors of 1,600-2,600 were obtained from a 10-min DI-SDME at 25°C with stirring. The limits of detections obtained by monitoring the absorbance at 214 nm were about 0.9-3 nM.
Language
English
URI
https://hdl.handle.net/10371/142494
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College of Natural Sciences (자연과학대학)Dept. of Chemistry (화학부)Theses (Master's Degree_화학부)
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