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A clinical study to investigate the effect of multidrug and toxin extrusion transporter inhibitor on pharmacokinetic characteristics and anti-hyperglycaemic activity of metformin : Multidrug and toxin extrusion 수송체 저해제가 메트포민의 약동학 특성 및 혈당 강하 효과에 미치는 영향 평가 연구
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- Authors
- Advisor
- 유경상
- Major
- 의과대학 의과학과
- Issue Date
- 2018-08
- Publisher
- 서울대학교 대학원
- Description
- 학위논문 (박사)-- 서울대학교 대학원 : 의과대학 의과학과, 2018. 8. 유경상.
- Abstract
- Introduction: Renal tubular secretion of metformin is mediated mainly via Multidrug And Toxin Extrusion (MATE) transporters at the apical membrane. We hypothesized that the anti-hyperglycaemic activity of metformin would change with inhibition of the MATE transporter.
Methods: Twenty healthy male subjects received 500 mg of metformin with and without 50 mg of pyrimethamine (a potent MATE inhibitor) twice daily, with 1 week of washout in between. The anti-hyperglycaemic activity of metformin were assessed for each period by administering the oral glucose tolerance test (OGTT) before and after the metformin dose
- Language
- English
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