Publications
Detailed Information
Virtually instantaneous, room-temperature [11C]-cyanation using biaryl phosphine Pd(0) complexes
Cited 58 time in
Web of Science
Cited 59 time in Scopus
- Authors
- Issue Date
- 2015-01
- Publisher
- American Chemical Society
- Citation
- Journal of the American Chemical Society, Vol.137 No.2, pp.648-651
- Abstract
- A new radiosynthetic protocol for the preparation of [C-11]aryl nitriles has been developed. This process is based on the direct reaction of in situ prepared L Pd(Ar)X complexes (L = biaryl phosphine) with [C-11]HCN. The strategy is operationally simple, exhibits a remarkably wide substrate scope with short reaction times, and demonstrates superior reactivity compared to previously reported systems. With this procedure, a variety of [C-11]nitrile-containing pharmaceuticals were prepared with high radiochemical efficiency.
- ISSN
- 0002-7863
- Language
- English
- Files in This Item:
- Appears in Collections:
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.