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Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ju, Ji-Min | - |
dc.contributor.author | Jung, Min Ho | - |
dc.contributor.author | Nam, Giri | - |
dc.contributor.author | Kim, Woojin | - |
dc.contributor.author | Oh, Sehwa | - |
dc.contributor.author | Kim, Hyun Duk | - |
dc.contributor.author | Kim, Joo Young | - |
dc.contributor.author | Chang, Jun | - |
dc.contributor.author | Lee, Sung Hak | - |
dc.contributor.author | Park, Gyeong Sin | - |
dc.contributor.author | Min, Chang-Ki | - |
dc.contributor.author | Lee, Dong-Sup | - |
dc.contributor.author | Kim, Moon Gyo | - |
dc.contributor.author | Choi, Kyungho | - |
dc.contributor.author | Choi, Eun Young | - |
dc.creator | 최은영 | - |
dc.date.accessioned | 2019-04-24T23:02:51Z | - |
dc.date.available | 2020-04-05T23:02:51Z | - |
dc.date.created | 2019-05-28 | - |
dc.date.created | 2019-05-28 | - |
dc.date.created | 2019-05-28 | - |
dc.date.issued | 2018-01 | - |
dc.identifier.citation | Nature Communications, Vol.9, p. 225 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | https://hdl.handle.net/10371/148779 | - |
dc.description.abstract | Whether hematopoietic cell-restricted distribution of antigens affects the degree of thymic negative selection has not been investigated in detail. Here, we show that T cells specific for hematopoietic cell-restricted antigens (HRA) are not completely deleted in the thymus, using the mouse minor histocompatibility antigen H60, the expression of which is restricted to hematopoietic cells. As a result, low avidity T cells escape from thymic deletion. This incomplete thymic deletion occurs to the T cells developing de novo in the thymus of H60-positive recipients in H60-mismatched bone marrow transplantation (BMT). H60-specific thymic deletion escapee CD8(+) T cells exhibit effector differentiation potentials in the periphery and contribute to graft-versus-leukemia effects in the recipients of H60-mismatched BMT, regressing H60(+) hematological tumors. These results provide information essential for understanding thymic negative selection and developing a strategy to treat hematological tumors. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Nature Publishing Group | - |
dc.title | Escape from thymic deletion and anti-leukemic effects of T cells specific for hematopoietic cell-restricted antigen | - |
dc.type | Article | - |
dc.identifier.doi | 10.1038/s41467-017-02665-z | - |
dc.citation.journaltitle | Nature Communications | - |
dc.identifier.wosid | 000422647600022 | - |
dc.identifier.scopusid | 2-s2.0-85040787212 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201800486 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A076144 | - |
dc.description.srnd | CITE_RATE:12.353 | - |
dc.description.srnd | DEPT_NM:의과학과 | - |
dc.description.srnd | EMAIL:eycii@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.startpage | 225 | - |
dc.citation.volume | 9 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Lee, Dong-Sup | - |
dc.contributor.affiliatedAuthor | Choi, Kyungho | - |
dc.contributor.affiliatedAuthor | Choi, Eun Young | - |
dc.identifier.srnd | T201800486 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | VERSUS-HOST-DISEASE | - |
dc.subject.keywordPlus | MINOR HISTOCOMPATIBILITY ANTIGEN | - |
dc.subject.keywordPlus | CENTRAL TOLERANCE | - |
dc.subject.keywordPlus | NEGATIVE SELECTION | - |
dc.subject.keywordPlus | CLONAL DELETION | - |
dc.subject.keywordPlus | SELF-ANTIGEN | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | QUANTITATIVE-ANALYSIS | - |
dc.subject.keywordPlus | LOW AVIDITY | - |
dc.subject.keywordPlus | CD4 HELP | - |
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