Publications
Detailed Information
Transient anosmia induces depressive-like and anxiolytic-like behavior and reduces amygdalar corticotropin-releasing hormone in a ZnSO4-induced mouse model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Sangzin | - |
dc.contributor.author | Choi, Mooseok | - |
dc.contributor.author | Kim, Hyunju | - |
dc.contributor.author | Yang, Eun-jeong | - |
dc.contributor.author | Mahmood, Usman | - |
dc.contributor.author | Kang, Seong-Il | - |
dc.contributor.author | Shin, Hyun-Woo | - |
dc.contributor.author | Kim, Dae Woo | - |
dc.contributor.author | Kim, Hye-Sun | - |
dc.creator | 김혜선 | - |
dc.date.accessioned | 2019-04-25T02:05:06Z | - |
dc.date.available | 2020-04-05T02:05:06Z | - |
dc.date.created | 2018-12-31 | - |
dc.date.issued | 2018-05 | - |
dc.identifier.citation | Chemical Senses, Vol.43 No.4, pp.213-221 | - |
dc.identifier.issn | 0379-864X | - |
dc.identifier.uri | https://hdl.handle.net/10371/150137 | - |
dc.description.abstract | Olfactory loss is known to affect both mood and quality of life. Transient anosmia was induced in mice to study the resulting changes in mood, behavior, and on a molecular level. Transient anosmia was induced by a single intranasal instillation of ZnSO4 in BALB/c mice. Hematoxylin and eosin (HE) staining, and potato chip finding test were performed to confirm olfactory loss. Tail suspension, forced swim, and splash tests were performed to evaluate depression-related behavior; while the open field, and elevated plus maze tests were used to evaluate anxiety-related behavior.The mRNA levels of amygdalar corticotropin-releasing hormone (CRH) and hypothalamic glucocorticoid receptor (GR) were quantified using real-time PCR to confirm relevant molecular change. Olfactory loss was confirmed 1-2.5 weeks after induction, and this loss was subsequently reversed over time. The results of the behavioral tests indicated increased depression-like and reduced anxiety-like behavior at week 1. Accordingly, PCR data identified decreased amygdalar CRH expression at week 1. These results suggest that transient anosmia induces both depressive and anxiolytic behavior as a result of decreased amygdalar CRH in a mouse model of anosmia. | - |
dc.language | 영어 | - |
dc.language.iso | en | en |
dc.publisher | Oxford University Press | - |
dc.title | Transient anosmia induces depressive-like and anxiolytic-like behavior and reduces amygdalar corticotropin-releasing hormone in a ZnSO4-induced mouse model | - |
dc.type | Article | - |
dc.identifier.doi | 10.1093/chemse/bjy008 | - |
dc.citation.journaltitle | Chemical Senses | - |
dc.identifier.wosid | 000431236000331 | - |
dc.identifier.scopusid | 2-s2.0-85046295931 | - |
dc.description.srnd | OAIID:RECH_ACHV_DSTSH_NO:T201733442 | - |
dc.description.srnd | RECH_ACHV_FG:RR00200001 | - |
dc.description.srnd | ADJUST_YN: | - |
dc.description.srnd | EMP_ID:A079472 | - |
dc.description.srnd | CITE_RATE:3.235 | - |
dc.description.srnd | DEPT_NM:의과학과 | - |
dc.description.srnd | EMAIL:hyisun@snu.ac.kr | - |
dc.description.srnd | SCOPUS_YN:Y | - |
dc.citation.endpage | 221 | - |
dc.citation.number | 4 | - |
dc.citation.startpage | 213 | - |
dc.citation.volume | 43 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Shin, Hyun-Woo | - |
dc.contributor.affiliatedAuthor | Kim, Hye-Sun | - |
dc.identifier.srnd | T201733442 | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TAIL-SUSPENSION TEST | - |
dc.subject.keywordPlus | ELEVATED PLUS-MAZE | - |
dc.subject.keywordPlus | UPPER RESPIRATORY-TRACT | - |
dc.subject.keywordPlus | QUALITY-OF-LIFE | - |
dc.subject.keywordPlus | GLUCOCORTICOID-RECEPTOR | - |
dc.subject.keywordPlus | OLFACTORY DYSFUNCTION | - |
dc.subject.keywordPlus | ANXIETY DISORDERS | - |
dc.subject.keywordPlus | PARAVENTRICULAR NUCLEUS | - |
dc.subject.keywordPlus | CONGENITAL ANOSMIA | - |
dc.subject.keywordPlus | FACTOR ANTAGONIST | - |
dc.subject.keywordAuthor | anxiety | - |
dc.subject.keywordAuthor | corticotropin-releasing hormone | - |
dc.subject.keywordAuthor | depression | - |
dc.subject.keywordAuthor | glucocorticoid receptor | - |
dc.subject.keywordAuthor | olfactory loss | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.