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Outcomes of hepatic resection for a single large hepatocellular carcinoma
Cited 40 time in
Web of Science
Cited 42 time in Scopus
- Authors
- Issue Date
- 2007-03-09
- Publisher
- Springer Verlag
- Citation
- World J Surg. 2007 Apr;31(4):795-801.
- Keywords
- Carcinoma, Hepatocellular/mortality/*surgery ; Disease-Free Survival ; Female ; Hepatectomy/*methods ; Humans ; Liver Neoplasms/mortality/*surgery ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local ; Postoperative Complications ; Prognosis ; Proportional Hazards Models ; Survival Rate ; Treatment Outcome
- Abstract
- BACKGROUND: The proper role of surgical resection, given the various treatment modalities available, needs to be further clarified in patients with a single large hepatocellular carcinoma (HCC). To evaluate the role of surgical resection in this group of patients, we studied the long-term outcomes of patients that received hepatic resection for a single large (> 5-10 cm in diameter) HCC. METHODS: The clinicopathologic data and long-term outcomes of 61 patients with a single large HCC (> 5-10 cm in diameter; L group) were compared with those of 169 patients with a single small HCC (< or = 5 cm; S group). Prognostic factors were evaluated by univariate and multivariate analysis. RESULTS: Operative mortality rates were low in both groups (0.6% in group S and 1.6% in group L), and the incidence of postoperative hepatic failure was rare even in group L (1.6%). The cumulative 5-year overall survival rate in group S was 59.0%, whereas in group L it was 52.9% (p = 0.385), and the corresponding cumulative 5-year disease-free survival rates were 44.1% and 31.7%, respectively (p = 0.063). Child class B was found to predict poor overall and disease-free survival by multivariate analysis versus Child class A in both groups. The presence of microvascular invasion was also identified as a significant prognostic factor, but it only affected disease-free survival in the two groups. CONCLUSIONS: Single large HCCs do not require a large extent of hepatic resection and the associated increased risk of postoperative liver failure. The long-term survival of patients with a single large HCC is as good as that of patients with a single small HCC. We conclude that hepatic resection is a safe and effective therapy for single large HCCs.
- ISSN
- 0364-2313 (Print)
- Language
- English
- URI
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17345125
https://hdl.handle.net/10371/15216
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