Browse

Effective local control of prostate cancer by intratumoral injection of (166)Ho-chitosan complex (DW-166HC) in rats

Cited 10 time in Web of Science Cited 10 time in Scopus
Authors
Kwak, Cheol; Hong, Sung Kyu; Seong, Seung Kyoo; Ryu, Jei Man; Park, Moon Soo; Lee, Sang Eun
Issue Date
2005-09-01
Publisher
Springer International
Citation
Eur J Nucl Med Mol Imaging. 2005 Dec;32(12):1400-5. Epub 2005 Aug 31.
Keywords
AnimalsBody Weight/radiation effectsChitin/administration & dosage/adverse effects/*analogs & derivativesHolmium/*administration & dosage/adverse effectsInjections, Intralesional/*methodsMaleOrganometallic Compounds/*administration & dosage/adverse effectsProstatic Neoplasms/*pathology/*radiotherapyRadioisotopes/*administration & dosage/adverse effectsRadiopharmaceuticals/administration & dosage/adverse effectsRatsSurvival RateTreatment Outcome
Abstract
PURPOSE: The aim of this study was to evaluate the therapeutic effect and morphological alterations resulting from (166)Ho-chitosan complex (DW-166HC) in an animal model of prostate cancer. METHODS: First, in a subcutaneous tumor model, 80 rats were randomly divided into four groups (n=20 in each group), and intratumoral injections of 0.05 ml (normal saline in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (10 mCi) in group 3, and DW-166HC solution (20 mCi) in group 4) were performed when the tumor measured approximately 1 cm along its long axis in each group. Further, in an orthotopic tumor model, 40 rats were similarly randomly divided into four groups (n=10 in each group), and intraprostatic injections of 0.05 ml [PBS in group 1,( 165)Ho-chitosan complex solution in group 2, DW-166HC solution (0.5 mCi) in group 3 and DW-166HC solution (1 mCi) in group 4] were performed at 1 week after implantation of the AIT cell line in the ventral prostate. RESULTS: In the subcutaneous tumor model, mean tumor weights of groups 3 and 4 were significantly lower than those of groups 1 and 2 at 2 and 4 weeks post injection (p<0.05). At 2 and 4 weeks after injection in the orthotopic tumor model, the mean weights of the prostate, including tumor, in groups 3 and 4 were also significantly lower than those in groups 1 and 2 (p<0.05). No adverse injury was seen in adjacent organs at histopathologic examination. CONCLUSION: Intratumoral injection of the beta-emitting radionuclide (166)Ho as a form of complex solution with chitosan appears to be a promising alternative therapeutic modality for the local control of prostate cancer.
ISSN
1619-7070 (Print)
Language
English
URI
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=16133378

http://hdl.handle.net/10371/15288
DOI
https://doi.org/10.1007/s00259-005-1892-y
Files in This Item:
There are no files associated with this item.
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Urology (비뇨기과학전공)Journal Papers (저널논문_비뇨기과학전공)
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse