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Enriched expression of NF1 in inhibitory neurons in both mouse and human brain

Cited 3 time in Web of Science Cited 3 time in Scopus
Authors
Ryu, Hyun-Hee; Kang, Minkyung; Park, Jinsil; Park, Sung-Hye; Lee, Yong-Seok
Issue Date
2019-06-24
Publisher
BioMed Central
Citation
Molecular Brain. 12(1):60
Keywords
Neurofibromatosis type 1NeurofibrominInhibitory neuronsRAS
Abstract
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease caused by loss-of-function mutations in NF1 gene, which encodes a GTPase activating protein for RAS. NF1 affects multiple systems including brain and is highly associated with cognitive deficits such as learning difficulties and attention deficits. Previous studies have suggested that GABAergic inhibitory neuron is the cell type primarily responsible for the learning deficits in mouse models of NF1. However, it is not clear how NF1 mutations selectively affect inhibitory neurons in the central nervous system. In this study, we show that the expression level of Nf1 is significantly higher in inhibitory neurons than in excitatory neurons in mouse hippocampus and cortex by using in situ hybridization. Furthermore, we also found that NF1 is enriched in inhibitory neurons in the human cortex, confirming that the differential expressions of NF1 between two cell types are evolutionarily conserved. Our results suggest that the enriched expression of NF1 in inhibitory neurons may underlie inhibitory neuron-specific deficits in NF1.
ISSN
1756-6606
Language
English
URI
https://hdl.handle.net/10371/156809
DOI
https://doi.org/10.1186/s13041-019-0481-0
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College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biomedical Sciences (대학원 의과학과)Journal Papers (저널논문_의과학과)
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Physiology (생리학교실)Journal Papers (저널논문_생리학교실)
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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