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High triglyceride/HDL cholesterol ratio is associated with silent brain infarcts in a healthy population

Cited 4 time in Web of Science Cited 7 time in Scopus
Authors
Nam, Ki-Woong; Kwon, Hyung-Min; Jeong, Han-Yeong; Park, Jin-Ho; Kwon, Hyuktae; Jeong, Su-Min
Issue Date
2019-07-02
Publisher
BioMed Central
Citation
BMC Neurology. 2019 Jul 02;19(1):147
Keywords
TriglyceridesHigh-density lipoproteinSilent brain infarctLacuneCerebral small vessel diseasesMetabolic syndrome
Abstract
Background
Triglycerides (TG)/high-density lipoprotein (HDL) cholesterol ratio is a marker of small/dense low-density lipoprotein particles, which are closely associated with various metabolic and vascular diseases. However, the role of TG/HDL cholesterol ratio in cerebrovascular diseases has not been well studied. In this study, we evaluated the relationship between TG/HDL cholesterol ratio and the presence of silent brain infarct (SBI) in a neurologically healthy population.

Methods
We retrospectively evaluated consecutive participants in health check-ups between January 2006 and December 2013. SBI was defined as an asymptomatic, well-defined lesion with a diameter of ≥3 mm on T1- or T2-weighted images. TG/HDL cholesterol ratio was calculated after dividing absolute TG levels by absolute HDL cholesterol levels.

Results
Of 3172 healthy participants, 263 (8.3%) had SBI lesions. In multivariate analysis, TG/HDL cholesterol ratio was independently associated with SBI (adjusted odds ratio [aOR] = 1.16, 95% confidence interval [CI] = 1.00 to 1.34, P = 0.047). This association was prominent in males (aOR = 1.23, 95% CI = 1.03 to 1.48, P = 0.021), but not in females. In the analyses of the relationships between lipid parameters and SBI lesion burden, TG/HDL cholesterol ratio was positively correlated, and total cholesterol/TG ratio was negatively correlated with SBI lesion burden, in dose-response manners (P for trend = 0.015 and 0.002, respectively).

Conclusions
The TG/HDL cholesterol ratio was positively associated with the prevalence of SBI in a neurologically healthy population.
ISSN
1471-2377
Language
English
URI
https://hdl.handle.net/10371/156816
DOI
https://doi.org/10.1186/s12883-019-1373-8
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College of Medicine/School of Medicine (의과대학/대학원)Family Medicine (가정의학전공)Journal Papers (저널논문_가정의학전공)
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