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Possible beneficial association between renin-angiotensin-aldosterone-system blockade usage and graft prognosis in allograft IgA nephropathy: a retrospective cohort study

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dc.contributor.authorPark, Sehoon-
dc.contributor.authorBaek, Chung Hee-
dc.contributor.authorGo, Heounjeong-
dc.contributor.authorKim, Young Hoon-
dc.contributor.authorMin, Sang–il-
dc.contributor.authorHa, Jongwon-
dc.contributor.authorKim, Yong Chul-
dc.contributor.authorLee, Jung Pyo-
dc.contributor.authorKim, Yon Su-
dc.contributor.authorMoon, Kyung Chul-
dc.contributor.authorPark, Su-Kil-
dc.contributor.authorLee, Hajeong-
dc.date.accessioned2019-11-07T04:59:19Z-
dc.date.available2019-11-07T14:00:07Z-
dc.date.issued2019-09-11-
dc.identifier.citationBMC Nephrology, 20(1):354ko_KR
dc.identifier.issn1471-2369-
dc.identifier.urihttps://hdl.handle.net/10371/162642-
dc.description.abstractBackground
Although immunoglobulin A nephropathy (IgAN) is associated with an increased risk of renal allograft failure, evidences for its treatment, including renin-angiotensin-aldosterone system blockade (RAASB) usage, remain limited.

Methods
In this bi-center retrospective cohort study, we included patients who were recently diagnosed with IgAN through allograft biopsies. We identified their 6-month antihypertensive medication prescriptions and investigated the association between the medication types, albuminuria changes, and risk of 5-year death-censored-graft-failure (DCGF). The mixed effect model and cox regression analysis were used.

Results
A total of 464 allograft IgAN patients were included: 272, 38, 33, and 121 patients in the no antihypertensive medication, single agent RAASB, single agent beta blocker (BB)/calcium channel blocker (CCB), and combination therapy groups, respectively. High-degree albuminuria after 6 months of allograft IgAN diagnosis was an important prognostic parameter and a partial mediator for the association between the subgroups and 5-year DCGF. The usage of single RAASB was associated with decrement of albuminuria from allograft IgAN diagnosis (P for interaction = 0.03). The single BB/CCB group demonstrated significantly worse prognosis than the single RAASB group (adjusted hazard ratio, 2.76 [1.09–6.98]; P = 0.03).

Conclusions
In conclusion, RAASB may be beneficial for graft prognosis in early allograft IgAN patients who require single antihypertensive medication therapy, by means of reducing albuminuria. Further investigation of treatment strategy in allograft IgAN is warranted.
ko_KR
dc.description.sponsorshipThis study was supported by a grant from the Ministry of Health and Welfare (No. HI15C2632), a grant from the National Research Foundation of Korea (No. 2019R1A2C2011465), and a grant from the Ministry of Science, ICT and Future Planning of Korea (No. 2015M3C9A2054342). The funder played no role in performing the study; the study was performed independently by the authors.ko_KR
dc.language.isoenko_KR
dc.publisherBioMed Centralko_KR
dc.subjectTransplantationko_KR
dc.subjectAllograftko_KR
dc.subjectIgA nephropathyko_KR
dc.subjectRenin-angiotensin-aldosterone systemko_KR
dc.subjectACE inhibitorsko_KR
dc.subjectAngiotensin receptor blockadeko_KR
dc.subjectProteinuriako_KR
dc.titlePossible beneficial association between renin-angiotensin-aldosterone-system blockade usage and graft prognosis in allograft IgA nephropathy: a retrospective cohort studyko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박세훈-
dc.contributor.AlternativeAuthor백충희-
dc.contributor.AlternativeAuthor고헌정-
dc.contributor.AlternativeAuthor김영훈-
dc.contributor.AlternativeAuthor민상일-
dc.contributor.AlternativeAuthor하종원-
dc.contributor.AlternativeAuthor김용철-
dc.contributor.AlternativeAuthor이정표-
dc.contributor.AlternativeAuthor문경철-
dc.contributor.AlternativeAuthor박수길-
dc.contributor.AlternativeAuthor이하정-
dc.identifier.doi10.1186/s12882-019-1537-1-
dc.language.rfc3066en-
dc.rights.holderThe Author(s).-
dc.date.updated2019-09-15T03:33:16Z-
Appears in Collections:
College of Medicine/School of Medicine (의과대학/대학원)Internal Medicine (내과학전공)Journal Papers (저널논문_내과학전공)
College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
College of Medicine/School of Medicine (의과대학/대학원)Dept. of Biomedical Sciences (대학원 의과학과)Journal Papers (저널논문_의과학과)
College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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