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A Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology

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dc.contributor.authorViventi, Jonathan-
dc.contributor.authorKim, Dae-Hyeong-
dc.contributor.authorMoss, Joshua D.-
dc.contributor.authorKim, Yun-Soung-
dc.contributor.authorBlanco, Justin A.-
dc.contributor.authorAnnetta, Nicholas-
dc.contributor.authorHicks, Andrew-
dc.contributor.authorXiao, Jianliang-
dc.contributor.authorHuang, Younggang-
dc.contributor.authorCallans, David J.-
dc.contributor.authorRogers, John A.-
dc.contributor.authorLitt, Brian-
dc.date.accessioned2020-02-17T04:33:22Z-
dc.date.available2020-02-17T04:33:22Z-
dc.date.issued2010-03-
dc.identifier.citationScience Translational Medicine, Vol.2 No.24, p. 24ra22-
dc.identifier.isbn1946-6234-
dc.identifier.issn1946-6234-
dc.identifier.other38432-
dc.identifier.urihttp://hdl.handle.net/10371/164351-
dc.description.abstractIn all current implantable medical devices such as pacemakers, deep brain stimulators, and epilepsy treatment devices, each electrode is independently connected to separate control systems. The ability of these devices to sample and stimulate tissues is hindered by this configuration and by the rigid, planar nature of the electronics and the electrode-tissue interfaces. Here, we report the development of a class of mechanically flexible silicon electronics for multiplexed measurement of signals in an intimate, conformal integrated mode on the dynamic, three-dimensional surfaces of soft tissues in the human body. We demonstrate this technology in sensor systems composed of 2016 silicon nanomembrane transistors configured to record electrical activity directly from the curved, wet surface of a beating porcine heart in vivo. The devices sample with simultaneous submillimeter and submillisecond resolution through 288 amplified and multiplexed channels. We use this system to map the spread of spontaneous and paced ventricular depolarization in real time, at high resolution, on the epicardial surface in a porcine animal model. This demonstration is one example of many possible uses of this technology in minimally invasive medical devices.-
dc.titleA Conformal, Bio-Interfaced Class of Silicon Electronics for Mapping Cardiac Electrophysiology-
dc.typeArticle-
dc.identifier.doi10.1126/scitranslmed.3000738-
dc.citation.journaltitleScience Translational Medicine-
dc.identifier.scopusid2-s2.0-77952995992-
dc.citation.number24-
dc.citation.startpage24ra22-
dc.citation.volume2-
dc.identifier.rimsid38432-
dc.identifier.sci000277304200003-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorKim, Dae-Hyeong-
Appears in Collections:
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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