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Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors
DC Field | Value | Language |
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dc.contributor.author | Lee, Jongha | - |
dc.contributor.author | Cho, Hye Rim | - |
dc.contributor.author | Cha, Gi Doo | - |
dc.contributor.author | Seo, Hyunseon | - |
dc.contributor.author | Lee, Seunghyun | - |
dc.contributor.author | Park, Chul-Kee | - |
dc.contributor.author | Kim, Jin Wook | - |
dc.contributor.author | Qiao, Shutao | - |
dc.contributor.author | Wang, Liu | - |
dc.contributor.author | Kang, Dayoung | - |
dc.contributor.author | Kang, Taegyu | - |
dc.contributor.author | Ichikawa, Tomotsugu | - |
dc.contributor.author | Kim, Jonghoon | - |
dc.contributor.author | Lee, Hakyong | - |
dc.contributor.author | Lee, Woongchan | - |
dc.contributor.author | Kim, Sanghoek | - |
dc.contributor.author | Lee, Soon-Tae | - |
dc.contributor.author | Lu, Nanshu | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Choi, Seung Hong | - |
dc.contributor.author | Kim, Dae-Hyeong | - |
dc.date.accessioned | 2020-03-13T07:56:15Z | - |
dc.date.available | 2020-03-13T07:56:15Z | - |
dc.date.created | 2020-02-04 | - |
dc.date.created | 2020-02-04 | - |
dc.date.issued | 2019-12 | - |
dc.identifier.citation | Nature Communications, Vol.10 No.1, p. 5205 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.other | 90616 | - |
dc.identifier.uri | https://hdl.handle.net/10371/164514 | - |
dc.description.abstract | Implantation of biodegradable wafers near the brain surgery site to deliver anti-cancer agents which target residual tumor cells by bypassing the blood-brain barrier has been a promising method for brain tumor treatment. However, further improvement in the prognosis is still necessary. We herein present novel materials and device technologies for drug delivery to brain tumors, i.e., a flexible, sticky, and biodegradable drug-loaded patch integrated with wireless electronics for controlled intracranial drug delivery through mild-thermic actuation. The flexible and bifacially-designed sticky/hydrophobic device allows conformal adhesion on the brain surgery site and provides spatially-controlled and temporarily-extended drug delivery to brain tumors while minimizing unintended drug leakage to the cerebrospinal fluid. Biodegradation of the entire device minimizes potential neurological side-effects. Application of the device to the mouse model confirms tumor volume suppression and improved survival rate. Demonstration in a large animal model (canine model) exhibited its potential for human application. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Flexible, sticky, and biodegradable wireless device for drug delivery to brain tumors | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.contributor.AlternativeAuthor | 박철기 | - |
dc.contributor.AlternativeAuthor | 김진욱 | - |
dc.contributor.AlternativeAuthor | 최승홍 | - |
dc.contributor.AlternativeAuthor | 김대형 | - |
dc.identifier.doi | 10.1038/s41467-019-13198-y | - |
dc.citation.journaltitle | Nature Communications | - |
dc.identifier.wosid | 000496713300002 | - |
dc.identifier.scopusid | 2-s2.0-85075115513 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 5205 | - |
dc.citation.volume | 10 | - |
dc.identifier.sci | 000496713300002 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Park, Chul-Kee | - |
dc.contributor.affiliatedAuthor | Kim, Jin Wook | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.contributor.affiliatedAuthor | Choi, Seung Hong | - |
dc.contributor.affiliatedAuthor | Kim, Dae-Hyeong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GLIOBLASTOMA | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | TEMOZOLOMIDE | - |
dc.subject.keywordPlus | ELECTRONICS | - |
dc.subject.keywordPlus | TRANSISTORS | - |
dc.subject.keywordPlus | CARMUSTINE | - |
dc.subject.keywordPlus | PHENOTYPES | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | THERAPY | - |
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