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Soft High-Resolution Neural Interfacing Probes: Materials and Design Approaches

Cited 11 time in Web of Science Cited 14 time in Scopus
Authors
Lee, Mincheol; Shim, Hyung Joon; Choi, Changsoon; Kim, Dae-Hyeong
Issue Date
2019-05
Citation
Nano Letters, Vol.19 No.5, pp.2741-2749
Keywords
Neural probesneural chronic recordingsoft electronicsbioelectronics
Abstract
Neural interfacing probes are located between the nervous system and the implanted electronic device in order to acquire information on the complex neuronal activity and to reconstruct impaired neural connectivity. Despite remarkable advancement in recent years, conventional neural interfacing is still unable to completely accomplish these goals, especially in long-term brain interfacing. The major limitation arises from physical and mechanical differences between neural interfacing probes and neural tissues that cause local immune responses and production of scar cells near the interface. Therefore, neural interfaces should ideally be extremely soft and have the physical scale of cells to mitigate the boundary between biotic and abiotic systems. Soft materials for neural interfaces have been intensively investigated to improve both interfacing and long-term signal transmission. The design and fabrication of micro and nanoscale devices have drastically decreased the stiffness of probes and enabled single-neuron measurement. In this Mini Review, we discuss materials and design approaches for developing soft high-resolution neural probes intended for long-term brain interfacing and outline existent challenges for achieving next-generation neural interfacing probes.
ISSN
1530-6984
URI
http://hdl.handle.net/10371/164519
DOI
https://doi.org/10.1021/acs.nanolett.8b04895
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