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Analysis of the effect of aging on the response to hypoxia by cDNA microarray

Cited 23 time in Web of Science Cited 23 time in Scopus
Authors
Kim, Hyungsoo; Lee, Dong-Ki; Choi, Ji-Woong; Kim, Jin-Soo; Park, Sang Chul; Youn, Hong-Duk
Issue Date
2003-08
Citation
Mechanisms of Ageing and Development, Vol.124 No.8-9, pp.941-949
Keywords
aginghypoxiacDNA microarrayhypoxia-inducible factorangiogenesis
Abstract
Little is known about the detail of hypoxia-responsive gene expression patterns in advanced age, even though aging is thought to be partially associated with a decreased response to hypoxia. In the present study, we identified several hypoxia-inducible genes and investigated the effect of aging on hypoxic gene expression profiles using cDNA microarray analysis of young/old human diploid fibroblasts. Of 7458 genes in the microarray, we found that genes involved in angiogenesis, defense against oxidative stress, and transcription regulation are severely impaired in senescent cell, which is consistent with the fact that aged cells have attenuated responses to various stimuli. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
ISSN
0047-6374
URI
http://hdl.handle.net/10371/165597
DOI
https://doi.org/10.1016/S0047-6374(03)00166-0
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