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Cas-Designer: a web-based tool for choice of CRISPR-Cas9 target sites
Cited 265 time in
Web of Science
Cited 248 time in Scopus
- Authors
- Issue Date
- 2015-12
- Publisher
- Oxford University Press
- Citation
- Bioinformatics, Vol.31 No.24, pp.4014-4016
- Abstract
- We present Cas-Designer, a user-friendly program to aid researchers in choosing appropriate target sites in a gene of interest for type II CRISPR/Cas-derived RNA-guided endonucleases, which are now widely used for biomedical research and biotechnology. Cas-Designer rapidly provides the list of all possible guide RNA sequences in a given input DNA sequence and their potential off-target sites including bulge-type sites in a genome of choice. In addition, the program assigns an out-of-frame score to each target site to help users choose appropriate sites for gene knockout. Cas-Designer shows the results in an interactive table and provides user-friendly filter functions.
- ISSN
- 1367-4803
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