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CRISPR-Pass: Gene Rescue of Nonsense Mutations Using Adenine Base Editors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Choongil | - |
dc.contributor.author | Jo, Dong Hyun | - |
dc.contributor.author | Hwang, Gue-Ho | - |
dc.contributor.author | Yu, Jihyeon | - |
dc.contributor.author | Kim, Jin Hyoung | - |
dc.contributor.author | Park, Se-eun | - |
dc.contributor.author | Kim, Jin-Soo | - |
dc.contributor.author | Kim, Jeong Hun | - |
dc.contributor.author | Bae, Sangsu | - |
dc.date.accessioned | 2020-04-27T13:02:16Z | - |
dc.date.available | 2020-04-27T13:02:16Z | - |
dc.date.created | 2019-11-11 | - |
dc.date.created | 2019-11-11 | - |
dc.date.created | 2019-11-11 | - |
dc.date.created | 2019-11-11 | - |
dc.date.issued | 2019-08 | - |
dc.identifier.citation | Molecular Therapy, Vol.27 No.8, pp.1364-1371 | - |
dc.identifier.issn | 1525-0016 | - |
dc.identifier.other | 85901 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165711 | - |
dc.description.abstract | A nonsense mutation is a substitutive mutation in a DNA sequence that causes a premature termination during translation and produces stalled proteins, resulting in dysfunction of a gene. Although it usually induces severe genetic disorders, there are no definite methods for inducing read through of premature termination codons (PTCs). Here, we present a targeted tool for bypassing PTCs, named CRISPR-pass, that uses CRISPR-mediated adenine base editors. CRISPR-pass, which should be applicable to 95.5% of clinically significant nonsense mutations in the ClinVar database, rescues protein synthesis in patient-derived fibroblasts, suggesting potential clinical utility. | - |
dc.language | 영어 | - |
dc.publisher | Nature Publishing Group | - |
dc.title | CRISPR-Pass: Gene Rescue of Nonsense Mutations Using Adenine Base Editors | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 김진수 | - |
dc.contributor.AlternativeAuthor | 김정훈 | - |
dc.identifier.doi | 10.1016/j.ymthe.2019.05.013 | - |
dc.citation.journaltitle | Molecular Therapy | - |
dc.identifier.wosid | 000479123200005 | - |
dc.identifier.scopusid | 2-s2.0-85066306256 | - |
dc.citation.endpage | 1371 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 1364 | - |
dc.citation.volume | 27 | - |
dc.identifier.sci | 000479123200005 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Jo, Dong Hyun | - |
dc.contributor.affiliatedAuthor | Kim, Jin-Soo | - |
dc.contributor.affiliatedAuthor | Kim, Jeong Hun | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | GENOMIC DNA | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | base editing | - |
dc.subject.keywordAuthor | CRISPR-Cas9 | - |
dc.subject.keywordAuthor | nonsense mutation | - |
dc.subject.keywordAuthor | premature termination codon | - |
dc.subject.keywordAuthor | stop codon read through | - |
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