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Magnetite/Ceria Nanoparticle Assemblies for Extracorporeal Cleansing of Amyloid-β in Alzheimer's Disease : Magnetite/Ceria Nanoparticle Assemblies for Extracorporeal Cleansing of Amyloid-beta in Alzheimer's Disease

Cited 76 time in Web of Science Cited 85 time in Scopus
Authors

Kim, Dokyoon; Kwon, Hyek Jin; Hyeon, Taeghwan

Issue Date
2019-05-10
Publisher
WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Citation
Advanced Materials, Vol.31 No.19, p. 1807965
Abstract
Accumulation of amyloid-beta (A beta) peptides in the brain is regarded as a major contributor to the pathogenesis and progression of Alzheimer's disease (AD). However, development of clinically relevant techniques to reduce A beta levels in AD patients is hindered by low efficiency and/or side effects. Here, an extracorporeal A beta cleansing system, where multifunctional magnetite/ceria nanoparticle assemblies are used to remove A beta peptides from flowing blood by specific capture and magnetic separation, is reported. The magnetite nanoparticles in the nanoassembly core enable the magnetic isolation of the captured A beta peptides by generating a large attraction force under an external magnetic field. The ceria nanoparticles in the nanoassembly shell relieve oxidative stress by scavenging reactive oxygen species that are produced by immune response during the process. Blood A beta cleansing treatment of 5XFAD transgenic mice not only demonstrates the decreased A beta levels both in the blood and in the brain but also prevents the spatial working memory deficits, suggesting the potential of the method for AD prevention and therapy.
ISSN
0935-9648
URI
https://hdl.handle.net/10371/165769
DOI
https://doi.org/10.1002/adma.201807965
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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