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Synthesis and biomedical applications of hollow nanostructures

Cited 313 time in Web of Science Cited 315 time in Scopus
Authors
An, Kwangjin; Hyeon, Taeghwan
Issue Date
2009-08
Citation
Nano Today, Vol.4 No.4, pp.359-373
Keywords
HollowNanoparticleKirkendall effectGalvanic replacementEtchingBiomedical applicationsTemplate synthesisDrug delivery vehicle
Abstract
Hollow nanostructures have attracted tremendous attention from researchers in various disciplines because their high surface to volume ratio and large pore volume are highly desirable for many technological applications including drug delivery system. Several colloidal synthetic methods have been used to synthesize various hollow nanostructures. These synthetic approaches are mainly categorized into four main classes according to how the hollow structure is formed: the Kirkendall effect, chemical etching, galvanic replacement, and template-mediated approach. The large pores inside the hollow nanostructures can encapsulate and release various drugs and biomolecules, while the surface of the nanostructure can be functionalized for drug targeting or bio-labeling. These features make the hollow nanostructures a unique and promising candidate as multifunctional drug delivery vehicles. This review article covers recent progress concerning the synthesis of hollow nanostructures with their sizes smaller than 200 nm and their biomedical, applications including specific targeting, imaging, and controlled release of therapeutics for simultaneous diagnosis and therapy. (C) 2009 Elsevier Ltd. All rights reserved.
ISSN
1748-0132
URI
https://hdl.handle.net/10371/165817
DOI
https://doi.org/10.1016/j.nantod.2009.06.013
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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