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Arginine-rich manganese silicate nanobubbles as a ferroptosis-inducing agent for tumor-targeted theranostics
DC Field | Value | Language |
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dc.contributor.author | Wang, Shuaifei | - |
dc.contributor.author | Li, Fangyuan | - |
dc.contributor.author | Qiao, Ruirui | - |
dc.contributor.author | Hu, Xi | - |
dc.contributor.author | Liao, Honrei | - |
dc.contributor.author | Chen, Lumin | - |
dc.contributor.author | Wu, Jiahe | - |
dc.contributor.author | Wu, Haibin | - |
dc.contributor.author | Zhao, Meng | - |
dc.contributor.author | Liu, Jianan | - |
dc.contributor.author | Chen, Rui | - |
dc.contributor.author | Ma, Xibo | - |
dc.contributor.author | Kim, Dokyoon | - |
dc.contributor.author | Sun, Jihong | - |
dc.contributor.author | Davis, Thomas P. | - |
dc.contributor.author | Chen, Chunying | - |
dc.contributor.author | Tian, Jie | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Ling, Daishun | - |
dc.date.accessioned | 2020-04-27T13:23:26Z | - |
dc.date.available | 2020-04-27T13:23:26Z | - |
dc.date.created | 2019-06-04 | - |
dc.date.issued | 2018-12 | - |
dc.identifier.citation | ACS Nano, Vol.12 No.12, pp.12380-12392 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.other | 74718 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165825 | - |
dc.description.abstract | Ferroptosis, an iron-based cell-death pathway, has recently attracted great attention owing to its effectiveness in killing cancer cells. Previous investigations focused on the development of iron-based nanomaterials to induce ferroptosis in cancer cells by the up-regulation of reactive oxygen species (ROS) generated by the well-known Fenton reaction. Herein, we report a ferroptosis-inducing agent based on arginine-rich manganese silicate nanobubbles (AMSNs) that possess highly efficient glutathione (GSH) depletion ability and thereby induce ferroptosis by the inactivation of glutathione-dependent peroxidases 4 (GPX4). The AMSNs were synthesized via a one-pot reaction with arginine (Arg) as the surface ligand for tumor homing. Subsequently, a significant tumor suppression effect can be achieved by GSH depletion-induced ferroptosis. Moreover, the degradation of AMSNs during the GSH depletion contributed to T-1-weighted magnetic resonance imaging (MRI) enhancement as well as on-demand chemotherapeutic drug release for synergistic cancer therapy. We anticipate that the GSH-depletion-induced ferroptosis strategy by using manganese-based nanomaterials would provide insights in designing nanomedicines for tumor-targeted theranostics. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Arginine-rich manganese silicate nanobubbles as a ferroptosis-inducing agent for tumor-targeted theranostics | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1021/acsnano.8b06399 | - |
dc.citation.journaltitle | ACS Nano | - |
dc.identifier.wosid | 000454567500061 | - |
dc.identifier.scopusid | 2-s2.0-85058537679 | - |
dc.citation.endpage | 12392 | - |
dc.citation.number | 12 | - |
dc.citation.startpage | 12380 | - |
dc.citation.volume | 12 | - |
dc.identifier.sci | 000454567500061 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | OXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | GLUTATHIONE LEVELS | - |
dc.subject.keywordPlus | CONTRAST | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | BIOLOGY | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | nanobubbles | - |
dc.subject.keywordAuthor | glutathione | - |
dc.subject.keywordAuthor | GPX4 | - |
dc.subject.keywordAuthor | ferroptosis | - |
dc.subject.keywordAuthor | theranostics | - |
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