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Simple synthesis of functionalized superparamagnetic magnetite/silica core/shell nanoparticles and their application as magnetically separable high-performance biocatalysts

Cited 321 time in Web of Science Cited 327 time in Scopus
Authors
Lee, Jinwoo; Lee, Youjin; Youn, Jong Kyu; Bin Na, Hyon; Yu, Taekyung; Kim, Hwan; Lee, Sang-Mok; Koo, Yoon-Mo; Kwak, Ja Hun; Park, Hyun Gyu; Chang, Ho Nam; Hwang, Misun; Park, Je-Geun; Kim, Jungbae; Hyeon, Taeghwan
Issue Date
2008-01
Citation
Small, Vol.4 No.1, pp.143-152
Keywords
core/shell materialsiron oxidessilicasuperparamagnetismsurface functionalization
Abstract
Uniformly sized silica-coated magnetic nanoparticles (magnetite@silica) are synthesized in a simple one-pot process using reverse micelles as nanoreactors. The core diameter of the magnetic nanoparticles is easily controlled by adjusting the w value ([polar solvent]/[surfactant]) in the reverse-micelle solution, and the thickness of the silica shell is easily controlled by varying the amount of tetraethyl orthosilicate added after the synthesis of the magnetite cores. Several grams of monodisperse magnetite@silica nanoparticles can be synthesized without going through any size-selection process. When crosslinked enzyme molecules form clusters on the surfaces of the magnetite@silica nanoparticles, the resulting hybrid composites are magnetically separable, highly active, and stable under harsh shaking conditions for more than 15 days. Conversely, covalently attached enzymes on the surface of the magnetite@silica nanoparticles are deactivated under the same conditions.
ISSN
1613-6810
URI
http://hdl.handle.net/10371/165848
DOI
https://doi.org/10.1002/smll.200700456
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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