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Ceria nanoparticle systems for selective scavenging of mitochondrial, intracellular, and extracellular reactive oxygen species in Parkinson's disease

Cited 187 time in Web of Science Cited 201 time in Scopus
Authors

Kwon, Hyek Jin; Kim, Dokyoon; Seo, Kyungho; Kim, Young Geon; Han, Sang Ihn; Kang, Taegyu; Soh, Min; Hyeon, Taeghwan

Issue Date
2018-07-20
Publisher
John Wiley & Sons Ltd.
Citation
Angewandte Chemie - International Edition, Vol.57 No.30, pp.9408-9412
Abstract
Oxidative stress induced by reactive oxygen species (ROS) is one of the critical factors that involves in the pathogenesis and progression of many diseases. However, lack of proper techniques to scavenge ROS depending on their cellular localization limits a thorough understanding of the pathological effects of ROS. Here, we demonstrate the selective scavenging of mitochondrial, intracellular, and extracellular ROS using three different types of ceria nanoparticles (NPs), and its application to treat Parkinson's disease (PD). Our data show that scavenging intracellular or mitochondrial ROS inhibits the microglial activation and lipid peroxidation, while protecting the tyrosine hydroxylase (TH) in the striata of PD model mice. These results indicate the essential roles of intracellular and mitochondrial ROS in the progression of PD. We anticipate that our ceria NP systems will serve as a useful tool for elucidating the functions of various ROS in diseases.
ISSN
1433-7851
URI
https://hdl.handle.net/10371/165865
DOI
https://doi.org/10.1002/anie.201805052
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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