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Responsive assembly of upconversion nanoparticles for pH-activated and near-infrared-triggered photodynamic therapy of deep tumors
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, Fangyuan | - |
dc.contributor.author | Du, Yang | - |
dc.contributor.author | Liu, Jianan | - |
dc.contributor.author | Sun, Heng | - |
dc.contributor.author | Wang, Jin | - |
dc.contributor.author | Li, Ruiqing | - |
dc.contributor.author | Kim, Dokyoon | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Ling, Daishun | - |
dc.date.accessioned | 2020-04-27T13:27:23Z | - |
dc.date.available | 2020-04-27T13:27:23Z | - |
dc.date.created | 2019-06-20 | - |
dc.date.issued | 2018-08-29 | - |
dc.identifier.citation | Advanced Materials, Vol.30 No.35, p. 1802808 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.other | 76296 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165880 | - |
dc.description.abstract | Upconversion nanoparticle (UCNP)-mediated photodynamic therapy has shown great effectiveness in increasing the tissue-penetration depth of light to combat deep-seated tumors. However, the inevitable phototoxicity to normal tissues resulting from the lack of tumor selectivity remains as a major challenge. Here, the development of tumor-pH-sensitive photodynamic nanoagents (PPNs) comprised of self-assembled photosensitizers grafted pH-responsive polymeric ligands and UCNPs is reported. Under neutral pH conditions, photosensitizers aggregated in the PPNs are self-quenched; however, upon entry into a tumor microenvironment with lower pH, the PPNs not only exhibit enhanced tumor-cell internalization due to charge reversal but also are further disassembled into well-dispersed nanoparticles in the endo/lysosomes of tumor cells, enabling the efficient activation of photosensitizers. The results demonstrate the attractive properties of both UCNP-mediated deep-tissue penetration of light and high therapeutic selectivity in vitro and in vivo. | - |
dc.language | 영어 | - |
dc.publisher | WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.title | Responsive assembly of upconversion nanoparticles for pH-activated and near-infrared-triggered photodynamic therapy of deep tumors | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1002/adma.201802808 | - |
dc.citation.journaltitle | Advanced Materials | - |
dc.identifier.wosid | 000442732400028 | - |
dc.identifier.scopusid | 2-s2.0-85050795034 | - |
dc.citation.number | 35 | - |
dc.citation.startpage | 1802808 | - |
dc.citation.volume | 30 | - |
dc.identifier.sci | 000442732400028 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | UPCONVERTING NANOPARTICLES | - |
dc.subject.keywordPlus | HIGHLY EFFICIENT | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | LIGHT | - |
dc.subject.keywordPlus | NANOTRANSDUCERS | - |
dc.subject.keywordPlus | NANOCRYSTALS | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | nanoassembly | - |
dc.subject.keywordAuthor | photodynamic therapy | - |
dc.subject.keywordAuthor | pH-responsive | - |
dc.subject.keywordAuthor | theranostics | - |
dc.subject.keywordAuthor | upconversion nanoparticle | - |
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