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Responsive assembly of upconversion nanoparticles for pH-activated and near-infrared-triggered photodynamic therapy of deep tumors

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dc.contributor.authorLi, Fangyuan-
dc.contributor.authorDu, Yang-
dc.contributor.authorLiu, Jianan-
dc.contributor.authorSun, Heng-
dc.contributor.authorWang, Jin-
dc.contributor.authorLi, Ruiqing-
dc.contributor.authorKim, Dokyoon-
dc.contributor.authorHyeon, Taeghwan-
dc.contributor.authorLing, Daishun-
dc.date.accessioned2020-04-27T13:27:23Z-
dc.date.available2020-04-27T13:27:23Z-
dc.date.issued2018-08-
dc.identifier.citationAdvanced Materials, Vol.30 No.35, p. 1802808-
dc.identifier.issn0935-9648-
dc.identifier.other76296-
dc.identifier.urihttps://hdl.handle.net/10371/165880-
dc.description.abstractUpconversion nanoparticle (UCNP)-mediated photodynamic therapy has shown great effectiveness in increasing the tissue-penetration depth of light to combat deep-seated tumors. However, the inevitable phototoxicity to normal tissues resulting from the lack of tumor selectivity remains as a major challenge. Here, the development of tumor-pH-sensitive photodynamic nanoagents (PPNs) comprised of self-assembled photosensitizers grafted pH-responsive polymeric ligands and UCNPs is reported. Under neutral pH conditions, photosensitizers aggregated in the PPNs are self-quenched; however, upon entry into a tumor microenvironment with lower pH, the PPNs not only exhibit enhanced tumor-cell internalization due to charge reversal but also are further disassembled into well-dispersed nanoparticles in the endo/lysosomes of tumor cells, enabling the efficient activation of photosensitizers. The results demonstrate the attractive properties of both UCNP-mediated deep-tissue penetration of light and high therapeutic selectivity in vitro and in vivo.-
dc.subjectnanoassembly-
dc.subjectphotodynamic therapy-
dc.subjectpH-responsive-
dc.subjecttheranostics-
dc.subjectupconversion nanoparticle-
dc.titleResponsive assembly of upconversion nanoparticles for pH-activated and near-infrared-triggered photodynamic therapy of deep tumors-
dc.typeArticle-
dc.contributor.AlternativeAuthor현택환-
dc.identifier.doi10.1002/adma.201802808-
dc.citation.journaltitleAdvanced Materials-
dc.identifier.scopusid2-s2.0-85050795034-
dc.citation.number35-
dc.citation.startpage1802808-
dc.citation.volume30-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/adma.201802808-
dc.identifier.rimsid76296-
dc.identifier.sci000442732400028-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorHyeon, Taeghwan-
Appears in Collections:
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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