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Surface design of magnetic nanoparticles for stimuli-responsive cancer imaging and therapy

Cited 158 time in Web of Science Cited 157 time in Scopus
Authors
Kang, Taegyu; Li, Fangyuan; Baik, Seungmin; Shao, Wei; Ling, Daishun; Hyeon, Taeghwan
Issue Date
2017-08
Citation
Biomaterials, Vol.136, pp.98-114
Keywords
Magnetic nanoparticlesStimuli-responsiveLigandControlled releaseCancer imagingCancer therapy
Abstract
Magnetic nanoparticles (MNPs) have been extensively studied for their potential applications to cancer diagnosis and treatment. However, various obstacles limit the use of nanoparticles for delivery in the tumor microenvironment. As a viable solution to such obstacles, advances in nanoparticle surface engineering augmented by a profound understanding of cancer physiology present new opportunities for MNP-based imaging and therapeutic agents. Stimuli-responsive ligands, rationally designed to interact with various physicochemical aspects, can improve the performance of MNPs in cancer-targeted imaging and therapy. In this review, we highlight recent progress in the design of MNP-based stimuli-responsive nanomaterials and their applications to cancer diagnosis and treatment.
ISSN
0142-9612
URI
http://hdl.handle.net/10371/165942
DOI
https://doi.org/10.1016/j.biomaterials.2017.05.013
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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