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pH-sensitive Pt nanocluster assembly overcomes cisplatin resistance and heterogeneous stemness of hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | Xia, Hongping | - |
dc.contributor.author | Li, Fangyuan | - |
dc.contributor.author | Hu, Xi | - |
dc.contributor.author | Park, Wooram | - |
dc.contributor.author | Wang, Shuaifei | - |
dc.contributor.author | Jang, Youngjin | - |
dc.contributor.author | Du, Yang | - |
dc.contributor.author | Baik, Seungmin | - |
dc.contributor.author | Cho, Soojeong | - |
dc.contributor.author | Kang, Taegyu | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.contributor.author | Ling, Daishun | - |
dc.contributor.author | Hui, Kam Man | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.date.accessioned | 2020-04-27T13:35:19Z | - |
dc.date.available | 2020-04-27T13:35:19Z | - |
dc.date.created | 2018-08-28 | - |
dc.date.issued | 2016-11 | - |
dc.identifier.citation | ACS Central Science, Vol.2 No.11, pp.802-811 | - |
dc.identifier.issn | 2374-7951 | - |
dc.identifier.other | 47512 | - |
dc.identifier.uri | https://hdl.handle.net/10371/165987 | - |
dc.description.abstract | Response rates to conventional chemotherapeutics remain unsatisfactory for hepatocellular carcinoma (HCC) due to the high rates of chemoresistance and recurrence. Tumor-initiating cancer stem-like cells (CSLCs) are refractory to chemotherapy, and their enrichment leads to subsequent development of chemoresistance and recurrence. To overcome the chemoresistance and stemness in HCC, we synthesized a Pt nanocluster assembly (Pt-NA) composed of assembled Pt nanoclusters incorporating a pH-sensitive polymer and HCC-targeting peptide. Pt-NA is latent in peripheral blood, readily targets disseminated HCC CSLCs, and disassembles into small Pt nanoclusters in acidic subcellular compartments, eventually inducing damage to DNA. Furthermore, treatment with Pt-NA downregulates a multitude of genes that are vital for the proliferation of HCC. Importantly, CD24+ side population (SP) CSLCs that are resistant to cisplatin are sensitive to Pt-NA, demonstrating the immense potential of Pt-NA for treating chemoresistant HCC. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | pH-sensitive Pt nanocluster assembly overcomes cisplatin resistance and heterogeneous stemness of hepatocellular carcinoma | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1021/acscentsci.6b00197 | - |
dc.citation.journaltitle | ACS Central Science | - |
dc.identifier.wosid | 000390864600008 | - |
dc.identifier.scopusid | 2-s2.0-85016853331 | - |
dc.citation.endpage | 811 | - |
dc.citation.number | 11 | - |
dc.citation.startpage | 802 | - |
dc.citation.volume | 2 | - |
dc.identifier.sci | 000390864600008 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | PLATINUM NANOPARTICLES | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | THERAPEUTIC-EFFICACY | - |
dc.subject.keywordPlus | SILVER NANOPARTICLES | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | SELF-RENEWAL | - |
dc.subject.keywordPlus | DNA-DAMAGE | - |
dc.subject.keywordPlus | PHARMACOKINETICS | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
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