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Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Ki Hyun | - |
dc.contributor.author | Park, Mihyun | - |
dc.contributor.author | Do, Min Jae | - |
dc.contributor.author | Lee, Nohyun | - |
dc.contributor.author | Ryu, Ji Hyun | - |
dc.contributor.author | Kim, Gun Woo | - |
dc.contributor.author | Kim, CheolGi | - |
dc.contributor.author | Park, Tae Gwan | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.date.accessioned | 2020-04-27T13:50:38Z | - |
dc.date.available | 2020-04-27T13:50:38Z | - |
dc.date.created | 2020-03-17 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | ACS Nano, Vol.6 No.6, pp.5266-5273 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.other | 92745 | - |
dc.identifier.uri | https://hdl.handle.net/10371/166186 | - |
dc.description.abstract | Magnetic nanoparticles have gained significant attention as a therapeutic agent for cancer treatment. Herein, we developed chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes (Chito-FIONs) as an effective heat nanomediator for cancer hyperthermia. Dynamic light scattering and transmission electron microscopic analyses revealed that Chito-FIONs were composed of multiple 30-nm-sized FIONs encapsulated by a chitosan polymer shell. Multiple FIONs in an interior increased the total magnetic moments, which leads to localized accumulation under an applied magnetic field. Chito-FIONs also exhibited superior magnetic heating ability with a high specific loss power value (2614 W/g) compared with commercial superparamagnetic Feridex nanoparticles (83 W/g). The magnetically guided Chito-FIONs successfully eradicated target cancer cells through caspase-mediated apoptosis. Furthermore, Chito-FIONs showed excellent antitumor efficacy on an animal tumor model without any severe toxicity. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Chitosan oligosaccharide-stabilized ferrimagnetic iron oxide nanocubes for magnetically modulated cancer hyperthermia | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1021/nn301046w | - |
dc.citation.journaltitle | ACS Nano | - |
dc.identifier.wosid | 000305661300078 | - |
dc.identifier.scopusid | 2-s2.0-84862860615 | - |
dc.citation.endpage | 5273 | - |
dc.citation.number | 6 | - |
dc.citation.startpage | 5266 | - |
dc.citation.volume | 6 | - |
dc.identifier.sci | 000305661300078 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MRI CONTRAST | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | FUNCTIONALIZATION | - |
dc.subject.keywordPlus | BIOMEDICINE | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | BILAYER | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | chitosan | - |
dc.subject.keywordAuthor | magnetite | - |
dc.subject.keywordAuthor | magnetic modulation | - |
dc.subject.keywordAuthor | nanocube | - |
dc.subject.keywordAuthor | cancer therapy | - |
dc.subject.keywordAuthor | hyperthermia | - |
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