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Ceria nanoparticles that can protect against ischemic stroke

Cited 236 time in Web of Science Cited 261 time in Scopus
Authors
Kim, Chi Kyung; Kim, Taeho; Choi, In-Young; Soh, Min; Kim, Dohoung; Kim, Young-Ju; Jang, Hyunduk; Yang, Hye-Sung; Kim, Jun Yup; Park, Hong-Kyun; Park, Seung Pyo; Park, Sangseung; Yu, Taekyung; Yoon, Byung-Woo; Lee, Seung-Hoon; Hyeon, Taeghwan
Issue Date
2012-10
Citation
Angewandte Chemie - International Edition, Vol.51 No.44, pp.11039-11043
Keywords
apoptosisceria nanoparticlesischemic strokereactive oxygen speciestherapeutic agents
Abstract
Uniform 3 nm-sized ceria nanoparticles can protect against ischemic stroke by scavenging reactive oxygen species (ROS) and reducing apoptosis. PEGylated ceria nanoparticles showed protective effects against ROS-induced cell death in vitro. Optimal doses of ceria nanoparticles reduced infarct volumes and the rate of ischemic cell death in vivo. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
ISSN
1433-7851
URI
http://hdl.handle.net/10371/166188
DOI
https://doi.org/10.1002/anie.201203780
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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