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Single step isolation and activation of primary CD3 + T lymphocytes using alcohol-dispersed electrospun magnetic nanofibers
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kwanghee | - |
dc.contributor.author | An, Hyo Jin | - |
dc.contributor.author | Jun, Seung-Hyun | - |
dc.contributor.author | Kim, Tae-Jin | - |
dc.contributor.author | Lim, Seon Ah | - |
dc.contributor.author | Park, Gayoung | - |
dc.contributor.author | Na, Hyon Bin | - |
dc.contributor.author | Park, Yong Il | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Yee, Cassian | - |
dc.contributor.author | Bluestone, Jeffrey A. | - |
dc.contributor.author | Kim, Jungbae | - |
dc.contributor.author | Lee, Kyung-Mi | - |
dc.date.accessioned | 2020-04-27T13:52:32Z | - |
dc.date.available | 2020-04-27T13:52:32Z | - |
dc.date.created | 2020-03-17 | - |
dc.date.issued | 2012-08 | - |
dc.identifier.citation | Nano Letters, Vol.12 No.8, pp.4018-4024 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.other | 92740 | - |
dc.identifier.uri | https://hdl.handle.net/10371/166207 | - |
dc.description.abstract | Electrospun polymer nanofibers with entrapped magnetic nanoparticles (magnetic NP-NF) represent a novel scaffold substrate that can be functionalized for single-step isolation and activation of specific lymphocyte subsets. Using a surface-embedded T cell receptor ligand/trigger (anti-CD3 monoclonal antibody), we demonstrate, as proof of principle, the use of magnetic NP-NF to specifically isolate, enrich, and activate CD3(+) T cells from a heterogeneous cell mixture, leading to preferential expansion of CD8(+)CD3(+) T cells. The large surface area, adjustable antibody density, and embedded paramagnetic properties of the NP-NF permitted enhanced activation and expansion; its use represents a strategy that is amenable to an efficient selection process for adoptive cellular therapy as well as for the isolation of other cellular subsets for downstream translational applications. | - |
dc.language | 영어 | - |
dc.publisher | American Chemical Society | - |
dc.title | Single step isolation and activation of primary CD3 + T lymphocytes using alcohol-dispersed electrospun magnetic nanofibers | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1021/nl301388d | - |
dc.citation.journaltitle | Nano Letters | - |
dc.identifier.wosid | 000307211000024 | - |
dc.identifier.scopusid | 2-s2.0-84864660595 | - |
dc.citation.endpage | 4024 | - |
dc.citation.number | 8 | - |
dc.citation.startpage | 4018 | - |
dc.citation.volume | 12 | - |
dc.identifier.sci | 000307211000024 | - |
dc.description.isOpenAccess | Y | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | CELL THERAPY | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | DURATION | - |
dc.subject.keywordPlus | SCAFFOLD | - |
dc.subject.keywordPlus | VIVO | - |
dc.subject.keywordAuthor | Electrospun magnetic nanofiber | - |
dc.subject.keywordAuthor | CD4(+) T lymphocytes | - |
dc.subject.keywordAuthor | CD8(+) T lymphocytes | - |
dc.subject.keywordAuthor | anti-CD3 monoclonal antibody | - |
dc.subject.keywordAuthor | immune cell therapy | - |
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