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Multiple-Interaction Ligands Inspired by Mussel Adhesive Protein: Synthesis of Highly Stable and Biocompatible Nanoparticles

Cited 97 time in Web of Science Cited 96 time in Scopus
Authors
Ling, Daishun; Park, Wooram; Park, Yong Il; Lee, Nohyun; Li, Fangyuan; Song, Changyeong; Yang, Su-Geun; Choi, Seung Hong; Na, Kun; Hyeon, Taeghwan
Issue Date
2011-11
Citation
Angewandte Chemie - International Edition, Vol.50 No.48, pp.11360-11365
Keywords
biocompatibilitycontrast agentscoordination modesnanoparticlespolymers
Abstract
All bound up: A poly(L-3,4-dihydroxyphenylalanine)-based ligand converts hydrophobic nanoparticles into hydrophilic and biocompatible species through several binding modes. Nanoparticles functionalized with this ligand (see picture) are highly stable in various aqueous solutions. A successful invivo MRI application using functionalized Fe 3O 4 nanoparticles confirmed their suitability for various biomedical applications.
ISSN
1433-7851
URI
http://hdl.handle.net/10371/166224
DOI
https://doi.org/10.1002/anie.201101521
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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