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Multifunctional capsule-in-capsules for immunoprotection and trimodal imaging

Cited 75 time in Web of Science Cited 74 time in Scopus
Authors

Kim, Jaeyun; Arifin, Dian R.; Muja, Naser; Kim, Taeho; Gilad, Assaf A.; Kim, Heechul; Arepally, Aravind; Hyeon, Taeghwan; Bulte, Jeff W. M.

Issue Date
2011
Publisher
John Wiley & Sons Ltd.
Citation
Angewandte Chemie - International Edition, Vol.50 No.10, pp.2317-2321
Abstract
(Figure Presented) The separate encapsulation of nanoparticles (NPs) and pancreatic islets in an alginate capsule-in-capsule (CIC) structure prevents the nanoparticles being toxic to the cells while housing a high payload of nanoparticles for imaging purposes (see picture). The CIC-encapsulated islets showed an improved insulin secretion over cells encapsulated in single capsules and their transplantation into diabetic mice restored normal glycemia. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA.
ISSN
1433-7851
URI
https://hdl.handle.net/10371/166226
DOI
https://doi.org/10.1002/anie.201007494
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area Chemistry, Materials Science

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