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Large-scale synthesis of bioinert tantalum oxide nanoparticles for X-ray computed tomography imaging and bimodal image-guided sentinel lymph node mapping

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dc.contributor.authorOh, Myoung Hwan-
dc.contributor.authorLee, Nohyun-
dc.contributor.authorKim, Hyoungsu-
dc.contributor.authorPark, Seung Pyo-
dc.contributor.authorPiao, Yuanzhe-
dc.contributor.authorLee, Jisoo-
dc.contributor.authorJun, Samuel Woojoo-
dc.contributor.authorMoon, Woo Kyung-
dc.contributor.authorChoi, Seung Hong-
dc.contributor.authorHyeon, Taeghwan-
dc.date.accessioned2020-04-27T13:56:26Z-
dc.date.available2020-04-27T13:56:26Z-
dc.date.created2020-03-18-
dc.date.issued2011-04-
dc.identifier.citationJournal of the American Chemical Society, Vol.133 No.14, pp.5508-5515-
dc.identifier.issn0002-7863-
dc.identifier.other92761-
dc.identifier.urihttps://hdl.handle.net/10371/166234-
dc.description.abstractEver since Au nanoparticles were developed as X-ray contrast agents, researchers have actively sought alternative nanoparticle-based imaging probes that are not only inexpensive but also safe for clinical use. Herein, we demonstrate that bioinert tantalum oxide nanoparticles are suitable nanoprobes for high-performance X-ray computed tomography (CT) imaging while simultaneously being cost-effective and meeting the criteria as a biomedical platform. Uniformly sized tantalum oxide nanoparticles were prepared using a microemulsion method, and their surfaces were readily modified using various silane derivatives through simple in situ sol-gel reaction. The silane-modified surface enabled facile immobilization of functional moieties such as polyethylene glycol (PEG) and fluorescent dye. PEG was introduced to endow the nanoparticles with biocompatibility and antifouling activity, whereas immobilized fluorescent dye molecules enabled simultaneous fluorescence imaging as well as X-ray CT imaging. The resulting nanoparticles exhibited remarkable performances in the in vivo X-ray CT angiography and bimodal image-guided lymph node mapping. We also performed an extensive study on in vivo toxicity of tantalum oxide nanoparticles, revealing that the nanoparticles did not affect normal functioning of organs.-
dc.language영어-
dc.publisherAmerican Chemical Society-
dc.titleLarge-scale synthesis of bioinert tantalum oxide nanoparticles for X-ray computed tomography imaging and bimodal image-guided sentinel lymph node mapping-
dc.typeArticle-
dc.contributor.AlternativeAuthor박원철-
dc.contributor.AlternativeAuthor현택환-
dc.contributor.AlternativeAuthor최승홍-
dc.contributor.AlternativeAuthor문우경-
dc.identifier.doi10.1021/ja200120k-
dc.citation.journaltitleJournal of the American Chemical Society-
dc.identifier.wosid000289829100052-
dc.identifier.scopusid2-s2.0-79953722845-
dc.citation.endpage5515-
dc.citation.number14-
dc.citation.startpage5508-
dc.citation.volume133-
dc.identifier.sci000289829100052-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorPiao, Yuanzhe-
dc.contributor.affiliatedAuthorMoon, Woo Kyung-
dc.contributor.affiliatedAuthorChoi, Seung Hong-
dc.contributor.affiliatedAuthorHyeon, Taeghwan-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusCOATED GOLD NANOPARTICLES-
dc.subject.keywordPlusFLUORESCENT SILICA NANOPARTICLES-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusMAGNETIC-RESONANCE-
dc.subject.keywordPlusQUANTUM DOTS-
dc.subject.keywordPlusCONTRAST AGENTS-
dc.subject.keywordPlusNONINVASIVE DETECTION-
dc.subject.keywordPlusMRI CONTRAST-
dc.subject.keywordPlusLIVE CELLS-
dc.subject.keywordPlusCANCER-
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area Chemistry, Materials Science

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