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Transformation of hydrophobic iron oxide nanoparticles to hydrophilic and biocompatible maghemite nanocrystals for use as highly efficient MRI contrast agent

Cited 51 time in Web of Science Cited 52 time in Scopus
Authors

Park, Yong Il; Piao, Yuanzhe; Lee, Nohyun; Yoo, Byeongjun; Kim, Byung Hyo; Choi, Seung Hong; Hyeon, Taeghwan

Issue Date
2011
Publisher
Royal Society of Chemistry
Citation
Journal of Materials Chemistry, Vol.21 No.31, pp.11472-11477
Abstract
We report a transformation of hydrophobic iron oxide nanoparticles to hydrophilic and biocompatible maghemite nanocrystals by controlled thermal treatment followed by dextran coating. Sodium sulfate salt was used as matrix for preventing aggregation during the thermal treatment at high temperature. Through the thermal treatment and subsequent isolation process, highly crystalline bare maghemite nanocrystals with high magnetization were produced. Subsequent coating with dextran derivatives produced hydrophilic and biocompatible iron oxide nanocrystals. Among various kinds of dextran derivatives, polyanionic carboxymethyl dextran (CM-dextran) was most efficient for stabilizing the nanocrystals in aqueous media. CM-dextran coated nanocrystals exhibited high relaxivity originating from the high magnetization and assembled structure.
ISSN
0959-9428
URI
https://hdl.handle.net/10371/166238
DOI
https://doi.org/10.1039/c1jm10432b
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area Chemistry, Materials Science

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