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Multimodal imaging of sustained drug release from 3-D poly(propylene fumarate) (PPF) scaffolds

Cited 45 time in Web of Science Cited 46 time in Scopus
Authors
Choi, Jonghoon; Kim, Kyobum; Kim, Taeho; Liu, Guanshu; Bar-Shir, Amnon; Hyeon, Taeghwan; McMahon, Michael T.; Bulte, Jeff W. M.; Fisher, John P.; Gilad, Assaf A.
Issue Date
2011-12
Citation
Journal of Controlled Release, Vol.156 No.2, pp.239-245
Keywords
NanoparticlesPoly(propylene fumarate) (PPF)Magnetic resonance imaging (MRI)Chemical exchange saturation transfer (CEST)Protamine sulfate (PS) drug releaseDoxorubicin
Abstract
The potential of poly(propylene fumarate) (PPF) scaffolds as drug carriers was investigated and the kinetics of the drug release quantified using magnetic resonance imaging (MRI) and optical imaging. Three different MR contrast agents were used for coating PPF scaffolds. Initially, iron oxide (IONP) or manganese oxide nanoparticles (MONP) carrying the anti-cancer drug doxorubicin were absorbed or mixed with the scaffold and their release into solution at physiological conditions was measured with MRI and optical imaging. A slow (hours to days) and functional release of the drug molecules into the surrounding solution was observed. In order to examine the release properties of proteins and polypeptides, protamine sulfate, a chemical exchange saturation transfer (CEST) MR contrast agent, was attached to the scaffold. Protamine sulfate showed a steady release rate for the first 24 h. Due to its biocompatibility, versatile drug-loading capability and constant release rate, the porous PPF scaffold has potential in various biomedical applications, including MR-guided implantation of drug-dispensing materials, development of drug carrying vehicles, and drug delivery for tumor treatment. (C) 2011 Elsevier B. V. All rights reserved.
ISSN
0168-3659
URI
https://hdl.handle.net/10371/166241
DOI
https://doi.org/10.1016/j.jconrel.2011.06.035
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
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