Browse

In vitro cytotoxicity screening of water-dispersible metal oxide nanoparticles in human cell lines

DC Field Value Language
dc.contributor.authorChoi, Jong Young-
dc.contributor.authorLee, Su Hee-
dc.contributor.authorNa, Hyon Bin-
dc.contributor.authorAn, Kwangjin-
dc.contributor.authorHyeon, Taeghwan-
dc.contributor.authorSeo, Tae Seok-
dc.date.accessioned2020-04-27T13:58:31Z-
dc.date.available2020-04-27T13:58:31Z-
dc.date.issued2010-01-
dc.identifier.citationBioprocess and Biosystems Engineering, Vol.33 No.1, pp.21-30-
dc.identifier.issn1615-7591-
dc.identifier.other92802-
dc.identifier.urihttps://hdl.handle.net/10371/166245-
dc.description.abstractIn this study, we present in vitro cytotoxicity of iron oxide (Fe3O4) and manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 mu g/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells). The surface of nanoparticles is modified with polyethyleneglycol-derivatized phospholipid to enhance the biocompatibility, water-solubility, and stability under an aqueous media. While the cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 mu g/ml, MnO nanoparticle represented higher level of toxicity than those of Fe3O4 and the commercial medical contrast reagent, Feridex after 2 and 4 day incubation time. However, the cytotoxicity of Fe3O4 is equivalent or better than Feridex based on the live/dead cell viability assay. The engineered MnO and Fe3O4 exhibited excellent stability compared with Feridex for a prolonged incubation time.-
dc.subjectWater-dispersible Fe3O4 and MnO nanoparticle-
dc.subjectMagnetic resonance imaging contrast agents-
dc.subjectCytotoxicity-
dc.subjectNanotoxicology-
dc.titleIn vitro cytotoxicity screening of water-dispersible metal oxide nanoparticles in human cell lines-
dc.typeArticle-
dc.contributor.AlternativeAuthor현택환-
dc.identifier.doi10.1007/s00449-009-0354-5-
dc.citation.journaltitleBioprocess and Biosystems Engineering-
dc.identifier.scopusid2-s2.0-76849101781-
dc.citation.endpage30-
dc.citation.number1-
dc.citation.startpage21-
dc.citation.volume33-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00449-009-0354-5-
dc.identifier.rimsid92802-
dc.identifier.sci000272910600003-
dc.description.isOpenAccessN-
dc.contributor.affiliatedAuthorHyeon, Taeghwan-
Appears in Collections:
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Chemical Convergence for Energy and Environment (에너지환경 화학융합기술전공)Journal Papers (저널논문_에너지환경 화학융합기술전공)
Files in This Item:
There are no files associated with this item.
  • mendeley

Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse