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In vitro cytotoxicity screening of water-dispersible metal oxide nanoparticles in human cell lines
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Jong Young | - |
dc.contributor.author | Lee, Su Hee | - |
dc.contributor.author | Na, Hyon Bin | - |
dc.contributor.author | An, Kwangjin | - |
dc.contributor.author | Hyeon, Taeghwan | - |
dc.contributor.author | Seo, Tae Seok | - |
dc.date.accessioned | 2020-04-27T13:58:31Z | - |
dc.date.available | 2020-04-27T13:58:31Z | - |
dc.date.created | 2020-03-18 | - |
dc.date.issued | 2010-01 | - |
dc.identifier.citation | Bioprocess and Biosystems Engineering, Vol.33 No.1, pp.21-30 | - |
dc.identifier.issn | 1615-7591 | - |
dc.identifier.other | 92802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/166245 | - |
dc.description.abstract | In this study, we present in vitro cytotoxicity of iron oxide (Fe3O4) and manganese oxide (MnO) using live/dead cell assay, lactate dehydrogenase assay, and reactive oxygen species detection with variation of the concentration of nanoparticles (5-500 mu g/ml), incubation time (18-96 h), and different human cell lines (lung adenocarcinoma, breast cancer cells, and glioblastoma cells). The surface of nanoparticles is modified with polyethyleneglycol-derivatized phospholipid to enhance the biocompatibility, water-solubility, and stability under an aqueous media. While the cytotoxic effect was negligible for 18 h incubation even at highest concentration of 500 mu g/ml, MnO nanoparticle represented higher level of toxicity than those of Fe3O4 and the commercial medical contrast reagent, Feridex after 2 and 4 day incubation time. However, the cytotoxicity of Fe3O4 is equivalent or better than Feridex based on the live/dead cell viability assay. The engineered MnO and Fe3O4 exhibited excellent stability compared with Feridex for a prolonged incubation time. | - |
dc.language | 영어 | - |
dc.publisher | Springer Verlag | - |
dc.title | In vitro cytotoxicity screening of water-dispersible metal oxide nanoparticles in human cell lines | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 현택환 | - |
dc.identifier.doi | 10.1007/s00449-009-0354-5 | - |
dc.citation.journaltitle | Bioprocess and Biosystems Engineering | - |
dc.identifier.wosid | 000272910600003 | - |
dc.identifier.scopusid | 2-s2.0-76849101781 | - |
dc.citation.endpage | 30 | - |
dc.citation.number | 1 | - |
dc.citation.startpage | 21 | - |
dc.citation.volume | 33 | - |
dc.identifier.sci | 000272910600003 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Hyeon, Taeghwan | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | MAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | MONODISPERSE NANOCRYSTALS | - |
dc.subject.keywordPlus | COLORIMETRIC ASSAY | - |
dc.subject.keywordPlus | CYTO-TOXICITY | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | NANOTOXICITY | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | VIVO | - |
dc.subject.keywordAuthor | Water-dispersible Fe3O4 and MnO nanoparticle | - |
dc.subject.keywordAuthor | Magnetic resonance imaging contrast agents | - |
dc.subject.keywordAuthor | Cytotoxicity | - |
dc.subject.keywordAuthor | Nanotoxicology | - |
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