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Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells
DC Field | Value | Language |
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dc.contributor.author | Jhun, Jooyeon | - |
dc.contributor.author | Min, Hong K | - |
dc.contributor.author | Ryu, Jaeyoon | - |
dc.contributor.author | Lee, Seon-Yeong | - |
dc.contributor.author | Ryu, Jun-Geol | - |
dc.contributor.author | Choi, Jeong W | - |
dc.contributor.author | Na, Hyun S | - |
dc.contributor.author | Lee, Seung Y | - |
dc.contributor.author | Jung, Yunju | - |
dc.contributor.author | Park, Sang-Jun | - |
dc.contributor.author | Park, Myeong S | - |
dc.contributor.author | Kwon, Bin | - |
dc.contributor.author | Ji, Geun E | - |
dc.contributor.author | Cho, Mi-La | - |
dc.contributor.author | Park, Sung-Hwan | - |
dc.date.accessioned | 2020-09-09T05:27:28Z | - |
dc.date.available | 2020-09-09T05:27:28Z | - |
dc.date.issued | 2020-08-15 | - |
dc.identifier.citation | Journal of Translational Medicine. 2020 Aug 15;18(1):317 | - |
dc.identifier.uri | https://doi.org/10.1186/s12967-020-02477-8 | - |
dc.identifier.uri | https://hdl.handle.net/10371/168868 | - |
dc.description.abstract | Abstract
Background To evaluate the immunomodulatory effect of Lactobacillus sakei in a mouse model of rheumatoid arthritis (RA) and in human immune cells. Methods We evaluated whether L. sakei reduced the severity of collagen-induced arthritis (CIA) and modulated interleukin (IL)-17 and IL-10 levels, as well as whether it affected the differentiation of CD4+ T cells and regulatory B cells. We evaluated osteoclastogenesis after culturing bone marrow-derived mononuclear cells with L. sakei. Results The differentiation of T helper 17 cells and the serum level of IL-17 were suppressed by L. sakei in both human peripheral blood mononuclear cells and mouse splenocytes. The serum level of IL-10 was significantly increased in the L. sakei-treated group, whereas the regulatory T cell population was unchanged. The population of regulatory B cells significantly increased the in L. sakei-treated group. Oral administration of L. sakei reduced the arthritis incidence and score in mice with CIA. Finally, osteoclastogenesis and the mRNA levels of osteoclast-related genes were suppressed in the L. sakei-treated group. Conclusion L. sakei exerted an anti-inflammatory effect in an animal model of RA, regulated Th17 and regulatory B cell differentiation, and suppressed osteoclastogenesis. Our findings suggest that L. sakei has therapeutic potential for RA. | - |
dc.title | Lactobacillus sakei suppresses collagen-induced arthritis and modulates the differentiation of T helper 17 cells and regulatory B cells | - |
dc.type | Journal Article | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.date.updated | 2020-08-16T03:20:40Z | - |
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