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Comparative analysis of the tonsillar microbiota in IgA nephropathy and other glomerular diseases

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dc.contributor.authorPark, Ji In-
dc.contributor.authorKim, Tae-Yoon-
dc.contributor.authorOh, Bumjo-
dc.contributor.authorCho, Hyunjeong-
dc.contributor.authorKim, Ji Eun-
dc.contributor.authorYoo, Seong Ho-
dc.contributor.authorLee, Jung Pyo-
dc.contributor.authorKim, Yon Su-
dc.contributor.authorChun, Jongsik-
dc.contributor.authorKim, Bong-Soo-
dc.contributor.authorLee, Hajeong-
dc.date.accessioned2021-01-29T02:23:03Z-
dc.date.available2021-01-29T02:23:03Z-
dc.date.created2020-11-02-
dc.date.created2020-11-02-
dc.date.created2020-11-02-
dc.date.created2020-11-02-
dc.date.created2020-11-02-
dc.date.issued2020-10-
dc.identifier.citationScientific Reports, Vol.10 No.1, p. 16206-
dc.identifier.issn2045-2322-
dc.identifier.other114669-
dc.identifier.urihttps://hdl.handle.net/10371/171734-
dc.description.abstractImmunoglobulin A nephropathy (IgAN) involves repeated events of gross haematuria with concurrent upper airway infections. The mucosal immune system, especially the tonsil, is considered the initial site of inflammation, although the role of the tonsillar microbiota has not been established in IgAN. In this study, we compared the tonsillar microbiota of patients with IgAN (n = 21) and other glomerular diseases (n = 36) as well as, healthy controls (n = 23) from three medical centres in Korea. The microbiota was analysed from tonsil swabs using the Illumina MiSeq system based on 16S rRNA gene. Tonsillar bacterial diversity was higher in IgAN than in other glomerular diseases, although it did not differ from that of healthy controls. Principal coordinates analysis revealed differences between the tonsillar microbiota of IgAN and both healthy and disease controls. The proportions of Rahnella, Ruminococcus_g2, and Clostridium_g21 were significantly higher in patients with IgAN than in healthy controls (corrected p < 0.05). The relative abundances of several taxa were correlated with the estimated glomerular filtration rate, blood urea nitrogen, haemoglobin, and serum albumin levels. Based on our findings, tonsillar microbiota may be associated with clinical features and possible immunologic pathogenesis of IgAN.-
dc.language영어-
dc.publisherNature Publishing Group-
dc.titleComparative analysis of the tonsillar microbiota in IgA nephropathy and other glomerular diseases-
dc.typeArticle-
dc.contributor.AlternativeAuthor유성호-
dc.contributor.AlternativeAuthor이정표-
dc.contributor.AlternativeAuthor김연수-
dc.contributor.AlternativeAuthor천종식-
dc.identifier.doi10.1038/s41598-020-73035-x-
dc.citation.journaltitleScientific Reports-
dc.identifier.wosid000577142600018-
dc.identifier.scopusid2-s2.0-85091742645-
dc.citation.number1-
dc.citation.startpage16206-
dc.citation.volume10-
dc.identifier.sci000577142600018-
dc.description.isOpenAccessY-
dc.contributor.affiliatedAuthorKim, Ji Eun-
dc.contributor.affiliatedAuthorYoo, Seong Ho-
dc.contributor.affiliatedAuthorLee, Jung Pyo-
dc.contributor.affiliatedAuthorKim, Yon Su-
dc.contributor.affiliatedAuthorChun, Jongsik-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.subject.keywordPlusSTEROID PULSE THERAPY-
dc.subject.keywordPlusTERM RENAL SURVIVAL-
dc.subject.keywordPlusCLINICAL REMISSION-
dc.subject.keywordPlusHAEMOPHILUS-PARAINFLUENZAE-
dc.subject.keywordPlusTONSILLECTOMY-
dc.subject.keywordPlusRISK-
dc.subject.keywordPlusGLOMERULONEPHRITIS-
dc.subject.keywordPlusPATHOGENESIS-
dc.subject.keywordPlusCANDIDATE-
dc.subject.keywordPlusMORTALITY-
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