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A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain

Cited 13 time in Web of Science Cited 13 time in Scopus
Authors
Liu, Jianan; Li, Fangyuan; Wang, Yi; Pan, Limin; Lin, Peihua; Zhang, Bo; Zheng, Yanrong; Xu, Yingwei; Liao, Hongwei; Ko, Giho; Fei, Fan; Xu, Cenglin; Du, Yang; Shin, Kwangsoo; Kim, Dokyoon; Jang, Sung-Soo; Chung, Hee Jung; Tian, He; Wang, Qi; Guo, Wei; Nam, Jwa-Min; Chen, Zhong; Hyeon, Taeghwan; Ling, Daishun
Issue Date
2020-04
Citation
Nature Nanotechnology, Vol.15 No.4, pp.321-330
Abstract
Extracellular potassium concentration affects the membrane potential of neurons, and, thus, neuronal activity. Indeed, alterations of potassium levels can be related to neurological disorders, such as epilepsy and Alzheimer's disease, and, therefore, selectively detecting extracellular potassium would allow the monitoring of disease. However, currently available optical reporters are not capable of detecting small changes in potassium, in particular, in freely moving animals. Furthermore, they are susceptible to interference from sodium ions. Here, we report a highly sensitive and specific potassium nanosensor that can monitor potassium changes in the brain of freely moving mice undergoing epileptic seizures. An optical potassium indicator is embedded in mesoporous silica nanoparticles, which are shielded by an ultrathin layer of a potassium-permeable membrane, which prevents diffusion of other cations and allows the specific capturing of potassium ions. The shielded nanosensor enables the spatial mapping of potassium ion release in the hippocampus of freely moving mice. Extracellular potassium levels in the brain can be correlated to neural activity. A selective potassium sensor, in which cations other than potassium are shielded by a membrane, can measure potassium concentration changes in the brain of freely moving mice undergoing epileptic seizures.
ISSN
1748-3387
URI
https://hdl.handle.net/10371/171761
DOI
https://doi.org/10.1038/s41565-020-0634-4
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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