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Nanovesicles derived from iron oxide nanoparticles-incorporated mesenchymal stem cells for cardiac repair

Cited 108 time in Web of Science Cited 108 time in Scopus

Lee, Ju-Ro; Park, Bong-Woo; Kim, Jonghoon; Choo, Yeon Woong; Kim, Han Young; Yoon, Jeong-Kee; Kim, Hyeok; Hwang, Ji-Won; Kang, Mikyung; Kwon, Sung Pil; Song, Seuk Young; Ko, In Ok; Park, Ji-Ae; Ban, Kiwon; Hyeon, Taeghwan; Park, Hun-Jun; Kim, Byung-Soo

Issue Date
American Association for the Advancement of Science
Science advances, Vol.6 No.18, p. eaaz0952
Because of poor engraftment and safety concerns regarding mesenchymal stem cell (MSC) therapy, MSC-derived exosomes have emerged as an alternative cell-free therapy for myocardial infarction (MI). However, the diffusion of exosomes out of the infarcted heart following injection and the low productivity limit the potential of clinical applications. Here, we developed exosome-mimetic extracellular nanovesicles (NVs) derived from iron oxide nanoparticles (IONPs)-incorporated MSCs (IONP-MSCs). The retention of injected IONP-MSC-derived NVs (IONP-NVs) within the infarcted heart was markedly augmented by magnetic guidance. Furthermore, IONPs significantly increased the levels of therapeutic molecules in IONP-MSCs and IONP-NVs, which can reduce the concern of low exosome productivity. The injection of IONP-NVs into the infarcted heart and magnetic guidance induced an early shift from the inflammation phase to the reparative phase, reduced apoptosis and fibrosis, and enhanced angiogenesis and cardiac function recovery. This approach can enhance the therapeutic potency of an MSC-derived NV therapy.
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  • College of Engineering
  • School of Chemical and Biological Engineering
Research Area Chemistry, Materials Science


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