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Nanovesicles derived from iron oxide nanoparticles-incorporated mesenchymal stem cells for cardiac repair

Cited 8 time in Web of Science Cited 6 time in Scopus
Authors
Lee, Ju-Ro; Park, Bong-Woo; Kim, Jonghoon; Choo, Yeon Woong; Kim, Han Young; Yoon, Jeong-Kee; Kim, Hyeok; Hwang, Ji-Won; Kang, Mikyung; Kwon, Sung Pil; Song, Seuk Young; Ko, In Ok; Park, Ji-Ae; Ban, Kiwon; Hyeon, Taeghwan; Park, Hun-Jun; Kim, Byung-Soo
Issue Date
2020-04
Citation
Science advances, Vol.6 No.18, p. eaaz0952
Abstract
Because of poor engraftment and safety concerns regarding mesenchymal stem cell (MSC) therapy, MSC-derived exosomes have emerged as an alternative cell-free therapy for myocardial infarction (MI). However, the diffusion of exosomes out of the infarcted heart following injection and the low productivity limit the potential of clinical applications. Here, we developed exosome-mimetic extracellular nanovesicles (NVs) derived from iron oxide nanoparticles (IONPs)-incorporated MSCs (IONP-MSCs). The retention of injected IONP-MSC-derived NVs (IONP-NVs) within the infarcted heart was markedly augmented by magnetic guidance. Furthermore, IONPs significantly increased the levels of therapeutic molecules in IONP-MSCs and IONP-NVs, which can reduce the concern of low exosome productivity. The injection of IONP-NVs into the infarcted heart and magnetic guidance induced an early shift from the inflammation phase to the reparative phase, reduced apoptosis and fibrosis, and enhanced angiogenesis and cardiac function recovery. This approach can enhance the therapeutic potency of an MSC-derived NV therapy.
ISSN
2375-2548
URI
http://hdl.handle.net/10371/171764
DOI
https://doi.org/10.1126/sciadv.aaz0952
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College of Engineering/Engineering Practice School (공과대학/대학원)Dept. of Chemical and Biological Engineering (화학생물공학부)Journal Papers (저널논문_화학생물공학부)
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