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Risk stratification of symptomatic brain metastases by clinical and FDG PET parameters for selective use of prophylactic cranial irradiation in patients with extensive disease of small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | Chung, Joo-Hyun | - |
dc.contributor.author | Kang, Seo Young | - |
dc.contributor.author | Wu, Hong-Gyun | - |
dc.contributor.author | Seo, Young Seok | - |
dc.contributor.author | Kim, Dong-Wan | - |
dc.contributor.author | Kang, Keon Wook | - |
dc.contributor.author | Kim, Hak Jae | - |
dc.contributor.author | Cheon, Gi Jeong | - |
dc.date.accessioned | 2021-01-31T08:07:34Z | - |
dc.date.available | 2021-01-31T08:07:34Z | - |
dc.date.created | 2020-05-14 | - |
dc.date.created | 2020-05-14 | - |
dc.date.created | 2020-05-14 | - |
dc.date.issued | 2020-02 | - |
dc.identifier.citation | Radiotherapy and Oncology, Vol.143, pp.81-87 | - |
dc.identifier.issn | 0167-8140 | - |
dc.identifier.other | 99612 | - |
dc.identifier.uri | https://hdl.handle.net/10371/171829 | - |
dc.description.abstract | Purpose: To identify risk factors for developing symptomatic brain metastases and evaluate the impact of prophylactic cranial irradiation (PCI) on brain metastasis-free survival (BMFS) and overall survival (OS) in extensive disease small cell lung cancer (ED-SCLC). Materials and methods: Among 190 patients diagnosed with ED-SCLC who underwent FDG PET/CT and brain Magnetic Resonance Imaging (MRI) prior to treatment, 53 (27.9%) received PCI while 137 (72.1%) did not. Prognostic index predicting a high risk of symptomatic brain metastases was calculated for the group without receiving PCI (observation group, n = 137) with Cox regression model. Results: Median follow-up time was 10.6 months. Multivariate Cox regression showed that the following three factors were associated with a high risk of symptomatic brain metastases: the presence of extrathoracic metastases (p = 0.004), hypermetabolism of bone marrow or spleen on FDG PET (p < 0.001), and high neutrophil-to-lymphocyte ratio (p = 0.018). PCI significantly improved BMFS in high-risk patients (1-year rate: 94.7% vs. 62.1%, p = 0.001), but not in low-risk patients (1-year rate: 100.0% vs. 87.7%, p = 0.943). However, PCI did not improve OS in patients at high risk for symptomatic brain metastases (1-year rate: 65.2% vs. 50.0%, p = 0.123). Conclusion: Three prognostic factors (the presence of extrathoracic metastases, hypermetabolism of bone marrow or spleen on FDG PET, and high neutrophil-to-lymphocyte ratio) were associated with a high risk of symptomatic brain metastases in ED-SCLC. PCI was beneficial for patients at a high risk of symptomatic brain metastases in terms of BMFS, but not OS. Thus, selective use of PCI in ED-SCLC according to the risk stratification is recommended. (C) 2020 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.publisher | Elsevier BV | - |
dc.title | Risk stratification of symptomatic brain metastases by clinical and FDG PET parameters for selective use of prophylactic cranial irradiation in patients with extensive disease of small cell lung cancer | - |
dc.type | Article | - |
dc.contributor.AlternativeAuthor | 천기정 | - |
dc.contributor.AlternativeAuthor | 김동완 | - |
dc.contributor.AlternativeAuthor | 김학재 | - |
dc.contributor.AlternativeAuthor | 강건욱 | - |
dc.contributor.AlternativeAuthor | 우홍균 | - |
dc.identifier.doi | 10.1016/j.radonc.2020.01.009 | - |
dc.citation.journaltitle | Radiotherapy and Oncology | - |
dc.identifier.wosid | 000519526300012 | - |
dc.identifier.scopusid | 2-s2.0-85079068036 | - |
dc.citation.endpage | 87 | - |
dc.citation.startpage | 81 | - |
dc.citation.volume | 143 | - |
dc.identifier.sci | 000519526300012 | - |
dc.description.isOpenAccess | N | - |
dc.contributor.affiliatedAuthor | Wu, Hong-Gyun | - |
dc.contributor.affiliatedAuthor | Kim, Dong-Wan | - |
dc.contributor.affiliatedAuthor | Kang, Keon Wook | - |
dc.contributor.affiliatedAuthor | Kim, Hak Jae | - |
dc.contributor.affiliatedAuthor | Cheon, Gi Jeong | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.subject.keywordPlus | TO-LYMPHOCYTE RATIO | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | EMISSION-TOMOGRAPHY | - |
dc.subject.keywordPlus | F-18-FDG UPTAKE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | IMPROVES | - |
dc.subject.keywordAuthor | [F-18]FDG PET | - |
dc.subject.keywordAuthor | ED-SCLC | - |
dc.subject.keywordAuthor | Symptomatic brain metastases | - |
dc.subject.keywordAuthor | Prophylactic cranial irradiation | - |
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